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Titolo:
Cadmium in caribou (Rangifer tarandus) kidneys: speciation, effects of preparation and toxicokinetics
Autore:
Chan, HM; Kim, C; Leggee, D;
Indirizzi:
McGill Univ, Ctr Indigenous Peoples Nutr & Environm, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ St Anne De Bellevue PQ Canada H9X 3V9 vue, PQ H9X 3V9, Canada McGill Univ, Sch Dietet & Human Nutr, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ St Anne De Bellevue PQ Canada H9X 3V9 vue, PQ H9X 3V9, Canada
Titolo Testata:
FOOD ADDITIVES AND CONTAMINANTS
fascicolo: 7, volume: 18, anno: 2001,
pagine: 607 - 614
SICI:
0265-203X(200107)18:7<607:CIC(TK>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL ABSORPTION; NORTHWEST-TERRITORIES; TEMPORAL TRENDS; METALLOTHIONEIN; MICE; EXPOSURE; CONTAMINANTS; CHLORIDE; TOXICITY; RATS;
Keywords:
cadmium speciation; caribou kidney; metallothionein; food preparation; absorption; accumulation; excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, HM McGill Univ, Ctr Indigenous Peoples Nutr & Environm, St Anne De Bellevue, PQ H9X 3V9, Canada McGill Univ St Anne De Bellevue PQ Canada H9X 3V9 9X 3V9, Canada
Citazione:
H.M. Chan et al., "Cadmium in caribou (Rangifer tarandus) kidneys: speciation, effects of preparation and toxicokinetics", FOOD ADDIT, 18(7), 2001, pp. 607-614

Abstract

Caribou kidney is a major source of cadmium (Cd) in the traditional diets of many aboriginal communities in the Arctic. In order to characterize the risk of Cd exposure, we studied the speciation of Cd in caribou kidneys andhow it can be affected by food preparation. Cd in caribou kidneys was bound to metallothionein (MT) (40%), high molecular weight proteins (50-500 kDa) (30%) and existed as free ions (10%). There was no change in Cd concentrations after the samples were baked at 350 degreesC for 30 min but the MT level was significantly decreased. Food preparation also denatured the high molecular weight proteins, resulting in a significant increase of free Cd. The toxicokinetics of Cd in caribou kidney was studied using a rodent model. Four groups (n = 6) of adult Sprague-Dawley rats were fed with rat chow with the addition of one of the following: 10% veal kidney with 0 mug/g Cd, 10% veal kidney spiked with CdCl2 to 66 mug/g Cd; 10% caribou kidney containing 20 mug/g Cd and 10% caribou kidney containing 66 mug/g Cd. After 14 days, Cd accumulation increased with dose but less than 1% of the dosed Cd accumulated in the liver and kidney of rats. The percentage of Cd accumulated in the liver was higher in the group fed with caribou kidney than that dosed with spiked veal kidney. Our results suggest that caribou kidney is a major source of Cd exposure among the Arctic populations but moderate consumption may be considered unavoidable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:27:21