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Titolo:
Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
Autore:
Dluzen, DE; Gao, XM; Story, GM; Anderson, LI; Kucera, J; Walro, JM;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 d, Dept Anat, Rootstown, OH 44272 USA Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 170, anno: 2001,
pagine: 121 - 128
SICI:
0014-4886(200107)170:1<121:EONDFI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL VENTRAL MESENCEPHALON; DISEASE SUBSTANTIA-NIGRA; NEUROTROPHIC FACTOR BDNF; NERVE GROWTH-FACTOR; AGE-RELATED-CHANGES; PARKINSONS-DISEASE; MESSENGER-RNA; GABAERGIC NEURONS; ESTROUS-CYCLE; BASAL GANGLIA;
Keywords:
brain-derived neurotrophic factor; neurotrophins; dopamine; corpus striatum; sensorimotor; locomotor activity; amphetamine; methamphetamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Dluzen, DE NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 t, Rootstown, OH 44272 USA
Citazione:
D.E. Dluzen et al., "Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice", EXP NEUROL, 170(1), 2001, pp. 121-128

Abstract

Deletion of a single copy of the BDNF gene has been shown to affect the nigrostriatal dopaminergic system of young adult BDNF mice. In the present report we evaluated various indices of nigrostriatal dopaminergic function between g-month-old wild-type (+/+) and heterozygous (+/-) BDNF mutant mice. performance in a sensorimotor beam walking task was significantly decreasedin +/- mice as indicated by increased times required to traverse both a wide (21 mm) and narrow (6 mm) beam. No differences in spontaneous locomotor behavior were observed between the +/+ and +/- mice. Amphetamine-stimulated(5 mg/kg) locomotor behavior was increased to a greater degree in the +/- mice, with the number of movements performed by these mice being significantly greater than their +/+ controls. Corpus striatal dopamine concentrations were significantly greater in the +/- BDNF mice. The absence of any significant differences for dopamine concentrations within the hypothalamus and olfactory bulb of these mice, as well as an absence of any difference in striatal norepinephrine concentrations, suggested a relative specificity of these effects to the corpus striatum. Both the +/- and +/+ mice showed similar reductions in striatal dopamine concentrations in response to a neurotoxic regimen of methamphetamine (20 mg/kg). Collectively these data show increased levels of striatal dopamine concentrations associated with altered behavioral responses involving the nigrostriatal dopaminergic system within the heterozygous BDNF mutant mice. (C) 2001 Academic Press.

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Documento generato il 02/04/20 alle ore 01:07:48