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Titolo:
Oxidative damage to mitochondria and aging
Autore:
Van Remmen, H; Richardson, A;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Physiol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 pt Physiol, San Antonio, TX 78284 USA S Texas Vet Hlth Care Syst, GRECC, San Antonio, TX 78284 USA S Texas Vet Hlth Care Syst San Antonio TX USA 78284 Antonio, TX 78284 USA
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 7, volume: 36, anno: 2001,
pagine: 957 - 968
SICI:
0531-5565(200107)36:7<957:ODTMAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY TRANSITION PORE; ADENINE-NUCLEOTIDE TRANSLOCASE; AGE-RELATED-CHANGES; CELL-DEATH; DIETARY RESTRICTION; SUBMITOCHONDRIAL PARTICLES; LIPID-PEROXIDATION; HYDROGEN-PEROXIDE; FOOD RESTRICTION; POINT MUTATIONS;
Keywords:
aging; oxidative damage; mitochondria;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Van Remmen, H Audie Murphy VA Hosp, GRECC 182, 7400 Merton Minter Blvd, San Antonio, TX 78229 USA Audie Murphy VA Hosp 7400 Merton Minter Blvd San Antonio TX USA 78229
Citazione:
H. Van Remmen e A. Richardson, "Oxidative damage to mitochondria and aging", EXP GERONT, 36(7), 2001, pp. 957-968

Abstract

Oxidative damage has been implicated to be a major factor in the decline in physiologic function that occurs during the aging process. Because mitochondria are a primary site of generation of reactive oxygen species, they have become a major focus of research in this area. Increased oxidative damage to mitochondrial proteins, lipid and DNA has been reported to occur with age in several tissues in a variety of organisms. Decreased activity of electron transport chain complexes and increased release of reactive oxygen species from the mitochondria with age suggest that alterations in mitochondrial function occur with age as a consequence of increased oxidative damage. In addition, age-related alterations in the mitochondrial pathway of apoptosis, which could have profound affects on the physiological function of a tissue, could arise from oxidative damage to mitochondria. Alterations in mitochondrial turnover with age could also contribute to an increase in the number of dysfunctional mitochondria with age. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:35:43