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Titolo:
Quantitative trait loci for body weight in the intercross between SM/J andA/J mice
Autore:
Anunciado, RVP; Nishimura, M; Mori, M; Ishikawa, A; Tanaka, S; Hori, F; Ohno, T; Namikawa, T;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Lab Anim Genet, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ, Sch Med, Inst Lab Anim Res, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Shinshu Univ, Sch Med, Res Ctr Aging & Adaptat, Dept Aging Angiol, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan Natl Chubu Hosp, Natl Inst Longev Sci, Aichi 4740031, Japan Natl Chubu Hosp Aichi Japan 4740031 nst Longev Sci, Aichi 4740031, Japan Nagoya Univ, Grad Sch Bioagr Sci, Div Biomodelling, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 a Ku, Nagoya, Aichi 4648601, Japan Univ Philippines, Coll Vet Med, Dept Vet Basic Sci, Laguna Coll, Los Banos4031, Philippines Univ Philippines Los Banos Philippines 4031 , Los Banos4031, Philippines
Titolo Testata:
EXPERIMENTAL ANIMALS
fascicolo: 4, volume: 50, anno: 2001,
pagine: 319 - 324
SICI:
1341-1357(200107)50:4<319:QTLFBW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTOR GENE; INBRED MOUSE STRAINS; COMPLEX TRAITS; OBESITY QTLS; SMXA; GROWTH; DISSECTION; INSULIN; ALLELES; PROFILE;
Keywords:
body weight; interval mapping mouse; quantitative trait loci (QTLs);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Namikawa, T Nagoya Univ, Grad Sch Bioagr Sci, Lab Anim Genet, Chikusa Ku, Nagoya, Aichi 4648601, Japan Nagoya Univ Nagoya Aichi Japan 4648601 , Aichi 4648601, Japan
Citazione:
R.V.P. Anunciado et al., "Quantitative trait loci for body weight in the intercross between SM/J andA/J mice", EXP ANIM, 50(4), 2001, pp. 319-324

Abstract

We performed a genome-wide quantitative trait locus (QTL) analysis of bodyweight at 10 weeks of age in a population of 321 intercross offspring fromSM/J and A/J mice, progenitor strains of SMXA recombinant inbred strains. interval mapping revealed two significant QTLs, Bwq3 (body weight QTL3) andBwq4, on Chromosomes (Chrs) 8 and 18 respectively, and five suggestive QTLs on Chrs 2, 6, 7, 15 and 19. Bwq3 and Bwq4 explained 6% of the phenotypic variance. The SM/J alleles at both QTLs increased body weight, though the SM/J mouse was smaller than the A/J mouse. On the other hand, four of the five suggestive QTLs detected had male-specific effects on body weight and the remainder was female-specific. These suggestive QTLs explained 5-6% of the phenotypic variance and all the SM/J alleles decreased body weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:21:35