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Titolo:
ABO/secretor genetic complex and susceptibility to asthma in childhood
Autore:
Ronchetti, F; Villa, MP; Ronchetti, R; Bonci, E; Latini, L; Pascone, R; Bottini, N; Gloria-Bottini, F;
Indirizzi:
Univ Roma Tor Vergata, Dipartimento Biopatol & Diagnost Immagini, Div Preventat & Social Paediat, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 al Paediat, I-00133 Rome, Italy Univ Roma Tor Vergata, Dept Internal Med, Div Allergol & Clin Immunol, Rome, Italy Univ Roma Tor Vergata Rome Italy v Allergol & Clin Immunol, Rome, Italy Univ Rome La Sapienza, Inst Pediat Clin, Rome, Italy Univ Rome La Sapienza Rome Italy apienza, Inst Pediat Clin, Rome, Italy
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 6, volume: 17, anno: 2001,
pagine: 1236 - 1238
SICI:
0903-1936(200106)17:6<1236:AGCAST>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Keywords:
ABO; age pattern; asthma; oligosaccharide structure; Secretor; sex pattern;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Gloria-Bottini, F Univ Roma Tor Vergata, Dipartimento Biopatol & Diagnost Immagini, Div Preventat & Social Paediat, Via Ricerca Sci, I-00133 Rome, Italy Univ Roma Tor Vergata Via Ricerca Sci Rome Italy I-00133
Citazione:
F. Ronchetti et al., "ABO/secretor genetic complex and susceptibility to asthma in childhood", EUR RESP J, 17(6), 2001, pp. 1236-1238

Abstract

A positive association has recently been reported in adult subjects between O/nonSecretor phenotype and asthma, To confirm this association, this study investigated the joint ABO/Secretor phenotype in a cohort of 165 asthmatic children, Three-hundred and sixty-two consecutive newborn infants from the same population were also studied as controls. The proportion of O/nonSecretor in asthmatic children was higher than in controls, thus confirming the association found in adults, The association was more marked in males than in females, In males, the pattern of association between the joint ABO/Secretor phenotype and asthma is dependent on the age at on-set of symptoms,Since the oligosaccharide composition of cell membrane and mucosal secretions is controlled by the cooperative interaction of ABO and Secretor genes,and since such composition influences the adhesion of infectious agents, the age pattern could reflect a more general interaction between developmental maturation and oligosaccharide structure concerning their effects on susceptibility to viral and bacterial agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:30:27