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Titolo:
Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD
Autore:
Ayers, ML; Mejia, R; Ward, J; Lentine, T; Mahler, DA;
Indirizzi:
Dartmouth Hitchcock Med Ctr, Dartmouth Med Sch, Dept Med, Pulm & Crit CareMed Sect, Lebanon, NH 03756 USA Dartmouth Hitchcock Med Ctr Lebanon NH USA03756 t, Lebanon, NH 03756 USA Natl Inst Resp Dis, Mexico City, DF, Mexico Natl Inst Resp Dis Mexico City DF Mexico sp Dis, Mexico City, DF, Mexico
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 6, volume: 17, anno: 2001,
pagine: 1132 - 1137
SICI:
0903-1936(200106)17:6<1132:EOSVIB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW LIMITATION; DYNAMIC HYPERINFLATION; INSPIRATORY CAPACITY; EXERCISE PERFORMANCE; LUNG HYPERINFLATION; BREATHLESSNESS;
Keywords:
bronchodilator therapy; dyspnoea ratings; inspiratory capacity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Mahler, DA Dartmouth Hitchcock Med Ctr, Dartmouth Med Sch, Dept Med, Pulm & Crit CareMed Sect, 1 Med Ctr Dr,3-D, Lebanon, NH 03756 USA Dartmouth Hitchcock Med Ctr 1 Med Ctr Dr,3-D Lebanon NH USA 03756
Citazione:
M.L. Ayers et al., "Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD", EUR RESP J, 17(6), 2001, pp. 1132-1137

Abstract

The hypothesis of the study was that salmeterol and ipratropium would havesimilar dyspnoea ratings during steady-state cycle ergometry at 1 h, but that salmeterol would reduce dyspnoea at 6 h after administration in patients with chronic obstructive pulmonary disease (COPD),The study design was a randomized, double-blind trial in 16 patients (aged63 +/- 11 yrs) with symptomatic CORD, Two days after familiarization with testing procedures, patients were randomly assigned to receive either two puffs (42 pg) of salmeterol and two puffs of placebo inhaler, or two puffs (36 mug) of ipratropium from each of two inhalers (total, 72 mug). Two days later, patients received the alternative medication. During exercise at 60%of peak oxygen consumption patients rated dyspnoea and performed inspiratory capacity manoeuvres each minute,Forced expiratory volume in one second was 1.13 +/-0.48 L (37 +/- 13% predicted). Dyspnoea ratings were similar for salmeterol and ipratropium at 1 and 6 h, Inspiratory capacity was similar for salmeterol and ipratropium at I h, but significantly higher for salmeterol at 6 h (Delta = 120 mL; p = 0.03),It is concluded that with the doses used, salmeterol and ipratropium provided similar dyspnoea ratings during exercise at 1 and 6 h after administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:05:21