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Titolo:
Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells
Autore:
Korn, SH; Jerre, A; Brattsand, R;
Indirizzi:
AstraZeneca R&D Operat, Inflammatory Pharmacol, S-22187 Lund, Sweden AstraZeneca R&D Operat Lund Sweden S-22187 armacol, S-22187 Lund, Sweden
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 6, volume: 17, anno: 2001,
pagine: 1070 - 1077
SICI:
0903-1936(200106)17:6<1070:EOFABO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; HUMAN LUNG FIBROBLASTS; SMOOTH-MUSCLE CELLS; GLUCOCORTICOID-RECEPTOR; BETA(2)-ADRENOCEPTOR AGONIST; INTERLEUKIN-8 RELEASE; ASTHMA; INHIBITION; ACTIVATION; SALMETEROL;
Keywords:
budesonide; beta(2)-agonist and glucocorticoid interactions; formoterol; granulocyte macrophage-colony stimulating factor; interleukin-8; triggered bronchial epithelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Brattsand, R AstraZeneca R&D Operat, Inflammatory Pharmacol, S-22187 Lund,Sweden AstraZeneca R&D Operat Lund Sweden S-22187 187 Lund, Sweden
Citazione:
S.H. Korn et al., "Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells", EUR RESP J, 17(6), 2001, pp. 1070-1077

Abstract

The effect of formoterol, alone and in combination with budesonide, upon tumour necrosis factor-a stimulated (10 ng.mL(-1)) human bronchial epithelial cells was investigated. Addition of formoterol (greater than or equal to 10(-10) M) reduced granulocyte macrophage-colony stimulating factor (GM-CSF) levels, as assessed by enzyme-linked immunosorbent assay, by 40-50% and increased interleukin (IL)-8 levels by similar to 50%. The effects of formoterol were long lasting (23 h), Budesonide (10(-8) M) reduced the amounts of both cytokines (GM-CSF and IL-8) by 40%. Simultaneous addition of formoterol and budesonide reducedGM-CSF levels similar to 75%, while IL-8 levels were decreased similar to 40% similar to the reduction obtained with budesonide alone. The glucocorticoid receptor (GR) antagonist RU486 did not influence the effect of formoterol, suggesting no involvement of the GR, Formoterol rapidly induced an elevation in intracellular cyclic adenosine monophosphate, which was reduced in the presence of propranolol, In addition, the alterations in cytokine secretion induced by formoterol could be fully blocked by propranolol, demonstrating that these effects are beta (2)-receptor mediated,In conclusion, the combination of budesonide and formoterol reduces the secretion of granulocyte macrophage-colony stimulating factor to basal le,elsand counteracts the capacity of formoterol alone to induce interleukin-8 production, modulations which may facilitate improved asthma control.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:51:20