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Titolo:
Heroin self-administration by means of 'chasing the dragon': pharmacodynamics and bioavailability of inhaled heroin
Autore:
Hendriks, VM; van den Brink, W; Blanken, P; Bosman, IJ; van Ree, JM;
Indirizzi:
Cent Comm Treatment Heroin Addicts CCBH, Stratenum, NL-3584 CG Utrecht, Netherlands Cent Comm Treatment Heroin Addicts CCBH Utrecht Netherlands NL-3584 CG s Parnassia Addict Res Ctr, Mental Hlth Inst Parnassia, The Hague, Netherlands Parnassia Addict Res Ctr The Hague Netherlands , The Hague, Netherlands Amsterdam Inst Addict Res, Amsterdam, Netherlands Amsterdam Inst Addict Res Amsterdam Netherlands Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Utrecht, Fac Pharm, Res Grp Human Toxicol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands rp Human Toxicol, Utrecht, Netherlands Univ Utrecht, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands us Inst Neurosci, Utrecht, Netherlands
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 241 - 252
SICI:
0924-977X(200106)11:3<241:HSBMO'>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRANASAL SNORTED HEROIN; ADDICTION SEVERITY INDEX; PHARMACOKINETICS; INSTRUMENT; EXCRETION; MORPHINE; OPIATES; SMOKING; HUMANS;
Keywords:
heroin; addiction; bioavailability; pharmacodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hendriks, VM Cent Comm Treatment Heroin Addicts CCBH, Stratenum, 5th Floor,Univ Weg 100, NL-3584 CG Utrecht, Netherlands Cent Comm Treatment Heroin Addicts CCBH 5th Floor,Univ Weg 100 Utrecht Netherlands NL-3584 CG
Citazione:
V.M. Hendriks et al., "Heroin self-administration by means of 'chasing the dragon': pharmacodynamics and bioavailability of inhaled heroin", EUR NEUROPS, 11(3), 2001, pp. 241-252

Abstract

In this controlled clinical study, the bioavailability and pharmacodynamics of inhaled heroin are evaluated and compared between 'chasing the dragon'and inhalation from a heating device, and at three dose levels, 25, 50 and100 mg heroin, in two separate study phases. In study phase I, no differences between the inhalation methods were detected on any of the physiological or behavioral measures, nor in bioavailability. Subjectively, the participants had a strong preference for the method of chasing. which was therefore used in study phase 2. In phase 2, heroin produced a dose-related increase in subjective drug-liking, body temperature and heart rate, and a clear, dose-related decline in reaction time. Linearly dose-related differences were found in the amount of total morphine in urine, amounting to an average of 45% of the parent heroin base received. Based on these findings, it is concluded that chasing is quite an effective route of heroin administration,producing rapid, dose-related subjective and objective effects and a sufficiently high and reproducible bioavailability. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:04:46