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Titolo:
The cAMP-dependent protein kinase substrate Rap1 in platelets from patients with obsessive compulsive disorder or schizophrenia
Autore:
Tardito, D; Maina, G; Tura, GB; Bogetto, F; Pioli, R; Ravizza, L; Racagni, G; Perez, J;
Indirizzi:
Univ Vita & Salute, Sch Med, Dept Neuropsychiat, Ist Sci San Raffaele, I-20127 Milan, Italy Univ Vita & Salute Milan Italy I-20127 an Raffaele, I-20127 Milan, Italy Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, Milan, Italy Univ Milan Milan Italy Pharmacol Sci, Ctr Neuropharmacol, Milan, Italy Univ Turin, Dept Neurosci, Turin, Italy Univ Turin Turin ItalyUniv Turin, Dept Neurosci, Turin, Italy Osped Sacro Cuore, IRCCS, Ctr San Giovanni Dio Fatebenefratelli, Brescia, Italy Osped Sacro Cuore Brescia Italy ni Dio Fatebenefratelli, Brescia, Italy
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 221 - 225
SICI:
0924-977X(200106)11:3<221:TCPKSR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; CYCLIC-AMP; POSTMORTEM BRAIN; MAJOR DEPRESSION; MAP KINASE; ENDOGENOUS PHOSPHORYLATION; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; MOOD DISORDERS; B-RAF;
Keywords:
Rap1; protein kinase (PKA); obsessive compulsive disorder; schizophrenia; platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Perez, J Univ Vita & Salute, Sch Med, Dept Neuropsychiat, Ist Sci San Raffaele, ViaStamira Ancona 20, I-20127 Milan, Italy Univ Vita & Salute Via Stamira Ancona 20 Milan Italy I-20127 aly
Citazione:
D. Tardito et al., "The cAMP-dependent protein kinase substrate Rap1 in platelets from patients with obsessive compulsive disorder or schizophrenia", EUR NEUROPS, 11(3), 2001, pp. 221-225

Abstract

Previous studies have reported that the cAMP-dependent protein kinase and one of its substrates, namely Rap1, are altered in patients with affective disorders. Abnormalities in the cAMP-dependent protein kinase have also been reported in platelets of patients with obsessive compulsive disorder and schizophrenia. However, it remains to be determined whether abnormalities in Rap1 are specifically related to affective disorders or may also be present in schizophrenia and obsessive compulsive disorder. Thus, we investigated Rap1 in platelets from 12 drug-free patients with obsessive compulsive disorder, ten drug-free patients with schizophrenia, and 20 healthy subjects. While no difference was observed in the levels of Rap1 between groups, thephosphorylation state of Rap1 was significantly lower in patients with obsessive compulsive disorder than in schizophrenic patients and controls. These data further support the idea that abnormalities of cAMP signalling pathway could be associated, albeit in a somewhat different way, with several psychiatric disorders. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.

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Documento generato il 05/12/20 alle ore 01:54:15