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Titolo:
The prolactin response to sulpiride in major depression: the role of the D-2 receptor in depression
Autore:
Verbeeck, WJC; Berk, M; Paiker, J; Jersky, B;
Indirizzi:
Univ Witwatersrand, Dept Psychiat, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Univ Witwatersrand, Dept Chem Pathol, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa Sonoma State Univ, Dept Math, Sonoma, CA USA Sonoma State Univ Sonoma CA USA ma State Univ, Dept Math, Sonoma, CA USA Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia Univ Melbourne Melbourne Vic Australia ychiat, Melbourne, Vic, Australia
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 215 - 220
SICI:
0924-977X(200106)11:3<215:TPRTSI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; DOPAMINE LEVELS; BINDING; PLACEBO; SEROTONIN; DISORDER; ANTIDEPRESSANTS; METOCLOPRAMIDE; AMITRIPTYLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, M Mental Hlth Swanston Ctr, POB 281, Geelong, Vic 3200, Australia Mental Hlth Swanston Ctr POB 281 Geelong Vic Australia 3200 tralia
Citazione:
W.J.C. Verbeeck et al., "The prolactin response to sulpiride in major depression: the role of the D-2 receptor in depression", EUR NEUROPS, 11(3), 2001, pp. 215-220

Abstract

Multiple lines of investigations have implicated the role of the dopaminergic system in depression. The aim of the study was to characterise the Dopamine D-2 receptor sensitivity status in depressed patients versus controls by means of a novel neuro-endocrine challenge test, the prolactin response to sulpiride. In this intervention, ten patients and ten age matched male volunteers were studied. The patients were diagnosed according to DSM-IV criteria, and Montgomery Asberg and Zung scales were done. There was no significant difference in baseline levels of prolactin between the depressed and control groups. Significantly higher prolactin levels after sulpiride challenge were however found in depressed patients than controls at all time points after sulpiride administration. This neuroendocrine challenge paradigm suggests that the prolactin response to sulpiride, a D-2 receptor antagonist, is enhanced in depression, which suggests that this receptor might be supersensitive in depression compared to controls. This adds to the data implicating the dopaminergic system in the pathophysiology of depression, and suggests that dopaminergic mechanisms might be a target of therapeutic interest. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:23:56