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Titolo:
Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: An autoradiographic study with alpha-[C-14]methyl-L-tryptophan
Autore:
Tohyama, Y; Yamane, F; Merid, MF; Diksic, M;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Cone NeurosurgRes Lab, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Lab, Montreal, PQ H3A 2B4, Canada Tokyo Womens Med Univ, Tokyo 1628666, Japan Tokyo Womens Med Univ Tokyo Japan 1628666 Med Univ, Tokyo 1628666, Japan
Titolo Testata:
EUROPEAN NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 11, anno: 2001,
pagine: 193 - 202
SICI:
0924-977X(200106)11:3<193:EOS5RA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-L-TRYPTOPHAN; DORSAL RAPHE; IN-VIVO; SYNTHESIS CAPACITY; LUMPED CONSTANT; FRONTAL-CORTEX; 5-HYDROXYTRYPTAMINE; WAY-100635; AUTORECEPTORS; FLUOXETINE;
Keywords:
alpha-methyl-L-tryptophan; Serotonin synthesis rate; WAY100135; WAY100635; 5-HT1A receptor antagonists; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Diksic, M McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, ConeNeurosurgRes Lab, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 real, PQ H3A 2B4, Canada
Citazione:
Y. Tohyama et al., "Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: An autoradiographic study with alpha-[C-14]methyl-L-tryptophan", EUR NEUROPS, 11(3), 2001, pp. 193-202

Abstract

The effects of acute and chronic administration of WAY 100635 and WAY100135, serotonin (5-HT)(1A) antagonists, on 5-HT synthesis rates, calculated from the trapping of alpha-[C-14]methyl-L-tryptophan (alpha -MTrp). were evaluated in the rat brain using autoradiography. In the acute treatment studies, WAY100635 (1 mg/kg) induced a significant increase in 5-HT synthesis in the median raphe nucleus and some nerve terminal structures (range between 18 and 53%), while WAY 100135 (10 mg/kg) produced a significant decrease ofsynthesis, in the range between 16 and 33%, in the raphe magnus nucleus and several projection areas. The action of WAY 100635 given acutely was likely a result of antagonist actions at the 5-HT1A somato-dendritic autoreceptors. WAY 100135 probably acted acutely as a partial agonist. In the chronictreatment studies, WAY100635 (1 mg/kg/day) and WAY100135 (10 mg/kg/day) were administered for 7 days as s.c. injections once a day. Chronic treatmentwith both compounds significantly reduced the rate of 5-HT synthesis in, the nerve terminal structures and produced a significant increase in the raphe nuclei. These treatments did not have any effect on the plasma free or total tryptophan. (C) 2001 Elsevier Science B.V./ECNP. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:58:20