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Titolo:
Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice
Autore:
Rajamani, K; Leong, S; Lavelle, A; Docherty, JR;
Indirizzi:
Royal Coll Surg Ireland, Dept Physiol, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 Dept Physiol, Dublin 2, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 423, anno: 2001,
pagine: 223 - 228
SICI:
0014-2999(20010706)423:2-3<223:PAOMIV>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRESYNAPTIC ALPHA(2)-AUTORECEPTORS; RAT ATRIUM; ALPHA-2-ADRENERGIC RECEPTOR; SUBMANDIBULAR-GLAND; SUBTYPES; ALPHA(2)-ADRENOCEPTOR; HEART; INHIBITION; ALPHA(2D); CORTEX;
Keywords:
MDMA (methylenedioxymethamphetamine); alpha(2)-adrenoceptor; alpha(2A/D)-adrenoceptor knockout; vas deferens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Docherty, JR Royal Coll Surg Ireland, Dept Physiol, 123 St Stephens Green,Dublin 2, Ireland Royal Coll Surg Ireland 123 St Stephens Green Dublin Ireland 2
Citazione:
K. Rajamani et al., "Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice", EUR J PHARM, 423(2-3), 2001, pp. 223-228

Abstract

Methylenedioxymethalnphetamine (MDMA, 'ecstasy') has major agonist actionsat prejunctional alpha (2A/D)-adrenoceptors in the rat. We wished to establish whether MDMA has potency at more than one subtype of alpha (2)-adrenoceptor, in line with affinity in ligand-binding studies. We have investigated the effects of MDMA in vas deferens from wild-type and from knockout micelacking the alpha (2A/D)-adrenoceptor. The potency of the alpha (2)-adrenoceptor agonist xylazine at inhibiting stimulation-evoked contractions to a single stimulus in the presence of cocaine was significantly reduced in knockout (pD(2) of 8.27 +/- 0.07, - log M, n = 4) as compared with wild-type mice (8.69 +/- 0.08, n = 4, P < 0.05), whereas potency of MDMA was unchanged(5.39 +/- 0.06, n = 4 versus 5.38 +/- 0.06, n = 6). Similar differences between xylazine and MDMA were seen fur responses to stimulation at 10 Hz for4 a. In studies of mouse atria pre-incubated with H-3-noradrenaline, the stimulation-evoked release of tritium was inhibited to a similar extent by MDMA (10 muM) in tissues from wild-type and knockout mice. The prejunctionalalpha (2A/D) adrenoceptor is reported to be replaced by the alpha (2C)-adrenocepror in this knockout mouse, so that we have evidence that suggests that MDMA has similar potencies at both subtypes in functional studies. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:35