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Titolo:
Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries
Autore:
Ayajiki, K; Fujioka, H; Okamura, T; Toda, N;
Indirizzi:
Shiga Univ Med Sci, Dept Pharmacol, Otsu, Shiga 52021, Japan Shiga Univ Med Sci Otsu Shiga Japan 52021 macol, Otsu, Shiga 52021, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 423, anno: 2001,
pagine: 179 - 183
SICI:
0014-2999(20010706)423:2-3<179:RSNNOS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROXIDERGIC NERVE FUNCTION; 7-NITRO INDAZOLE; VASODILATOR NERVE; NEURAL MECHANISM; ISOLATED DOG; IN-VIVO; ACETYLCHOLINE; ENDOTHELIUM; MODULATION;
Keywords:
nitric oxide (NO); nitric oxide synthase (NOS) inhibitor; vasodilator nerve; cerebral artery; (monkey);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Toda, N Nippon Shinyaku Co Ltd, Minami Ku, Kisshoin Monguchi Cho, Kyoto 6018550, Japan Nippon Shinyaku Co Ltd Kisshoin Monguchi Cho Kyoto Japan 6018550
Citazione:
K. Ayajiki et al., "Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries", EUR J PHARM, 423(2-3), 2001, pp. 179-183

Abstract

The selectivity of 7-nitroindazole in inhibiting endothelial and neuronal nitric oxide synthases (eNOS and nNOS) was investigated by comparing its inhibitory action on relaxations mediated by nitric oxide (NO) in response tostimulation of perivascular nerves and in response to histamine in monkey cerebral artery strips. 7-Nitroindazole at 2 x 10(-5) M moderately attenuated the response to transmural electrical stimulation and to nicotine, but did to alter the endothelium-dependent relaxation in response to histamine in cimetidine-treated strips. Raising the concentration of 7-nitroindazole to 10(-4) M abolished the neurogenic response, partially inhibited the histamine-induced relaxation, but did not affect the response to NO. It is concluded that 7-nitroindazole is a relatively selective nNOS inhibitor; however, at high concentrations, it inhibits eNOS in monkey cerebral arteries. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:08:29