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Titolo:
Cytokines in the liver
Autore:
Ramadori, G; Armbrust, T;
Indirizzi:
Univ Gottingen, Dept Gastroenterol & Endocrinol, D-37075 Gottingen, Germany Univ Gottingen Gottingen Germany D-37075 nol, D-37075 Gottingen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 7, volume: 13, anno: 2001,
pagine: 777 - 784
SICI:
0954-691X(200107)13:7<777:CITL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HEPATOCYTE GROWTH-FACTOR; HEPATIC STELLATE CELLS; ACUTE-PHASE RESPONSE; MONOCYTE CHEMOTACTIC PROTEIN-1; A-INDUCED HEPATITIS; RAT KUPFFER CELLS; TNF-ALPHA; INTERLEUKIN-6-DEFICIENT MICE; FACTOR-BETA;
Keywords:
cytokines; hepatic acute phase response; hepatic stellate cells; hepatocytes; interferon; interleukins; Kupffer cells; liver development; liver fibrosis; liver injury; liver metastasis; sinusoidal endothelial cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Ramadori, G Univ Gottingen, Dept Gastroenterol & Endocrinol, Robert Koch Str 40, D-37075 Gottingen, Germany Univ Gottingen Robert Koch Str 40 Gottingen Germany D-37075 y
Citazione:
G. Ramadori e T. Armbrust, "Cytokines in the liver", EUR J GASTR, 13(7), 2001, pp. 777-784

Abstract

Cytokines comprise a group of small proteins released from cells in order to influence the function of other cells. By binding to highly specific cell-surface receptors, they trigger a vast array of intracellular signalling cascades. Cytokines have been described as interleukins, growth factors, interferons and chemokines, Unlike hormones, which act in a similar way, cytokines are produced by many different types of cell and act on many other types. Most of them are produced only after certain stimuli. The most intensefield of cytokine activity is without doubt host defence. The liver resembles a central organ of cytokine activity due to the fact that it hosts hepatocytes, which are highly susceptible to the activity of cytokines in a variety of physiological and pathophysiological processes, Moreover, the non-parenchymal cells of the liver, in particular Kupffer cells(KCs), the resident tissue macrophages of the liver, are able to synthesize a variety of cytokines that may act systemically on any other organ of the body, or in a paracrine manner on hepatocytes and other nonparenchymal liver cells. A classic example of how cytokines act can be observed during the acute phase reaction discussed in this article, The role of cytokines in liver development, acute liver injury, liver regeneration, liver fibrosis and liver metastasis is also discussed. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 08:21:26