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Titolo:
Defensins - innate immunity at the epithelial frontier
Autore:
Fellermann, K; Stange, EF;
Indirizzi:
Med Univ Lubeck, Dept Internal Med 1, Div Gastroenterol, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 oenterol, D-23538 Lubeck, Germany
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 7, volume: 13, anno: 2001,
pagine: 771 - 776
SICI:
0954-691X(200107)13:7<771:D-IIAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; HUMAN BETA-DEFENSINS; NATURAL PEPTIDE ANTIBIOTICS; HUMAN INTESTINAL DEFENSIN-5; FACTOR KAPPA-B; HUMAN BETA-DEFENSIN-2; MESSENGER-RNA; HOST-DEFENSE; ANTIMICROBIAL PEPTIDES; INDUCIBLE EXPRESSION;
Keywords:
antimicrobial peptide; defensin; epithelial cell; innate immunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Fellermann, K Med Univ Lubeck, Dept Internal Med 1, Div Gastroenterol, Ratzeburger Allee160, D-23538 Lubeck, Germany Med Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538
Citazione:
K. Fellermann e E.F. Stange, "Defensins - innate immunity at the epithelial frontier", EUR J GASTR, 13(7), 2001, pp. 771-776

Abstract

Physical barrier function was formerly believed to play the major role in mucosal protection against luminal bacteria. This view has now been challenged by the discovery of specialized molecules that possess antimicrobial activity, More than 100 peptides have been identified so far, and the number is still growing, These peptides are distributed widely and conserved throughout phylogeny, The epithelial expression of antimicrobial peptides is of particular interest as many pathogens adhere to epithelial surfaces and mayeventually invade the host. This rapidly acting defence system of innate immunity is already engaged before adoptive immune interactions take place, These antimicrobial peptides consist of constitutive and inducible forms, potentiating this barrier function in terms of an inflammatory response,One important subgroup of antimicrobial peptides is the family of defensins, which are classified as alpha (alpha-) and beta (beta-) defensins, Eightdifferent peptides with varying antimicrobial properties have been identified. They are distributed widely in humans, and organ-specific expression patterns have been observed. Homologous peptides have been found in other mammals, vertebrates, invertebrates, insects and plants, The identification of alpha -defensins and their murine counterparts, cryptdins, in the small intestine prompted intensive research into epithelial antimicrobial defence. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:20:28