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Titolo:
Transforming growth factor beta and myocardial dysfunction following hearttransplantation
Autore:
Aziz, T; Saad, RA; Burgess, M; Yonan, N; Hasleton, P; Hutchinson, IV;
Indirizzi:
Wythenshawe Hosp, Transplant Unit, Manchester M23 9LT, Lancs, England Wythenshawe Hosp Manchester Lancs England M23 9LT M23 9LT, Lancs, England
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 177 - 186
SICI:
1010-7940(200107)20:1<177:TGFBAM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOTOPIC CARDIAC TRANSPLANTATION; DOPPLER ECHOCARDIOGRAPHIC INDEXES; LEFT-VENTRICULAR FUNCTION; DIASTOLIC FUNCTION; TGF-BETA; REJECTION; PROLIFERATION; HYPERTENSION; ALLOGRAFT; BICAVAL;
Keywords:
transforming growth factor-beta; heart transplantation; echocardiography; left ventricular dysfunction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Aziz, T Freeman Rd Hosp, Transplant Unit, Freeman Rd,High Heaton, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England Freeman Rd Hosp Freeman Rd,High Heaton Newcastle Upon Tyne Tyne & Wear England NE7 7DN
Citazione:
T. Aziz et al., "Transforming growth factor beta and myocardial dysfunction following hearttransplantation", EUR J CAR-T, 20(1), 2001, pp. 177-186

Abstract

Objective: We analyzed the role of transforming growth factor-beta (TGF-beta), a fibrogenic cytokine, in the development of left ventricular diastolic dysfunction following heart transplantation. Methods: We studied 152 heart transplant recipients who had survived for at least 24 months. We compared histopathological findings (staining of endomyocardial biopsy specimens using Heamatoxlin Eosin and polyclonal antibodies), left ventricular function (Doppler echocardiography) and clinical course (NYHA status}. Patients are classified into group A (n = 56 recipients) with immunohistochemical TGF-beta staining score >7 and group B (n = 96 recipients) with a staining score <7. Results: Doppler echocardiographic evaluation demonstrated greater impairment of left ventricular diastolic function in recipients with higher TGF-beta staining score. The average mitral deceleration time was 129 +/- 6 ms for recipients group A compared to 167 +/- 15 ms in group B. While the mean isovolumic relaxation rime was 65 +/- 8 ms for patients in group A compared with 82 +/- 6 ms for recipients in group B (P = 0.0004 and 0.005, respectively). Immunohistochemical scoring correlated inversely with both mitral deceleration and isovolumic relaxation times (r = -0.74, P = 0.0004 and r= -0.66, P = 0.004, respectively). Mean NYHA status was 2.7 +/- 1.3 for group A compared to 1.17 +/- 0.4 in group 8 was (P = 0.002). Five years follow-up revealed persistent left ventricular diastolic impairment for recipients with higher immunohistochemical staining score. Mitral deceleration timeand isovolumic relaxation time were 118 +/- 11 and 62 +/- 7 ms for group Acompared to 156 +/- 12 and 80 +/- 5 ms for group B, P = 0.006 and P = 0.01, respectively. The actuarial development of subsequent coronary artery disease (> 50% stenosis) was 17 and 29% for recipients in group A compared to 4 and 6% for recipients in group B at 3 and 5 years follow-up, respectively(P = 0.01 and P = 0.005, respectively). Conclusions: TGF-beta expression in cardiac allografts is associated with impaired graft function and limitedsurvival. The pathogenesis of diastolic dysfunction may be an aberrant repair process following rejection due to increased TGF-beta expression in transplant recipients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:08:42