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Titolo:
A genetic look at the active site of RNA polymerase III
Autore:
Rozenfeld, S; Thuriaux, P;
Indirizzi:
CEA Saclay, Serv Biochim & Genet Mol, F-91191 Gif Sur Yvette, France CEA Saclay Gif Sur Yvette France F-91191 F-91191 Gif Sur Yvette, France
Titolo Testata:
EMBO REPORTS
fascicolo: 7, volume: 2, anno: 2001,
pagine: 598 - 603
SICI:
1469-221X(200107)2:7<598:AGLATA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION INITIATION; SACCHAROMYCES-CEREVISIAE; LARGEST SUBUNIT; MUTATIONS; CLEAVAGE; ARCHITECTURE; SUPPRESSION; RESIDUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Thuriaux, P CEA Saclay, Serv Biochim & Genet Mol, Bat 142, F-91191 Gif SurYvette, France CEA Saclay Bat 142 Gif Sur Yvette France F-91191 ette, France
Citazione:
S. Rozenfeld e P. Thuriaux, "A genetic look at the active site of RNA polymerase III", EMBO REP, 2(7), 2001, pp. 598-603

Abstract

rpc160-112 a mutant of the RNA polymerase III active site, is I corrected in vivo by six second-site mutants obtained by random mutagenesis. These mutants introduce single-site amino acid replacements at the two large subunits of the enzyme. The mutated motifs are conserved in RNA polymerases I andII and, for some of them, in the bacterial enzyme, thus delineating key elements of the active site in eukaryotic RNA polymerases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:02:06