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Titolo:
Association between the endogenous retrovirus HRES-1 and multiple sclerosis in the United Kingdom - evidence of genetically different disease subsets?
Autore:
Rasmussen, HB; Kelly, MA; Francis, DA; Clausen, J;
Indirizzi:
Roskilde Univ, Dept Chem & Life Sci, DK-4000 Roskilde, Denmark Roskilde Univ Roskilde Denmark DK-4000 fe Sci, DK-4000 Roskilde, Denmark Univ Birmingham, Dept Med, Div Med Sci, Birmingham B15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT W Midlands, England Queen Elizabeth Med Ctr, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Med Ctr Birmingham W Midlands England B15 2TH ds, England
Titolo Testata:
DISEASE MARKERS
fascicolo: 3-4, volume: 16, anno: 2000,
pagine: 101 - 104
SICI:
0278-0240(2000)16:3-4<101:ABTERH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY; ALLELES; ORIGIN;
Keywords:
multiple sclerosis; endogenous retrovirus; genetic susceptibility factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Rasmussen, HB Roskilde Univ, Dept Chem & Life Sci, POB 260, DK-4000 Roskilde, Denmark Roskilde Univ POB 260 Roskilde Denmark DK-4000 lde, Denmark
Citazione:
H.B. Rasmussen et al., "Association between the endogenous retrovirus HRES-1 and multiple sclerosis in the United Kingdom - evidence of genetically different disease subsets?", DIS MARKER, 16(3-4), 2000, pp. 101-104

Abstract

In the present study we determined the frequencies of four haplotypes of the human T-cell lymphotropic virus-related endogenous sequence, HRES-1, in 110 multiple sclerosis (MS) patients and 100 healthy control subjects from the United Kingdom. We found evidence of an association between this endogenous retrovirus and MS (p < 0.01), in particular reflecting an increased frequency of HRES-1 haplotype 1 in the group of patients. There was no significant difference in the distribution of HRES-1 haplotypes between relapsing-remitting MS and the primary progressive form of the disease. The odds ratio for HRES-1 haplotype 1 and MS did not differ significantly between individuals positive for HLA-DR2 and DR2-negative individuals. Comparison of theobservations from the present study with previous results implicated HRES-1 as a marker of genetic heterogeneity in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:33:54