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Titolo:
Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons
Autore:
Huang, EJ; Liu, W; Fritzsch, B; Bianchi, LM; Reichardt, LF; Xiang, MQ;
Indirizzi:
UMDNJ, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Grad ProgramMol Genet & Microbiol, Piscataway, NJ 08854 USA UMDNJ Piscataway NJ USA 08854 Genet & Microbiol, Piscataway, NJ 08854 USA UMDNJ, Robert Wood Johnson Med Sch, Dept Pediat, Piscataway, NJ 08854 USA UMDNJ Piscataway NJ USA 08854 Sch, Dept Pediat, Piscataway, NJ 08854 USA Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA Oberlin Coll, Neurosci Program, Oberlin, OH 44074 USA Oberlin Coll Oberlin OH USA 44074 Neurosci Program, Oberlin, OH 44074 USA Univ Calif San Francisco, Dept Physiol, Neurosci Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 13, volume: 128, anno: 2001,
pagine: 2421 - 2432
SICI:
0950-1991(200107)128:13<2421:BIATRO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; DOMAIN FACTOR BRN-3B; LIM HOMEOBOX GENES; MOTOR-NEURONS; TRIGEMINAL GANGLION; NERVOUS-SYSTEM; EXPRESSION; MICE; DIFFERENTIATION; SPECIFICATION;
Keywords:
Brn3a; POU domain; transcription factor; spiral ganglion; vestibular ganglion; innervation; axon pathfinding; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Xiang, MQ UMDNJ, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Grad ProgramMol Genet & Microbiol, Piscataway, NJ 08854 USA UMDNJ PiscatawayNJ USA 08854 crobiol, Piscataway, NJ 08854 USA
Citazione:
E.J. Huang et al., "Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons", DEVELOPMENT, 128(13), 2001, pp. 2421-2432

Abstract

The POU domain transcription factors Brn3a, Brn3b and Brn3c are required for the proper development of sensory ganglia, retinal ganglion cells, and inner ear hair cells, respectively. We have investigated the roles of Brn3a in neuronal differentiation and target innervation in the facial-stato-acoustic ganglion. We show that absence of Brn3a results in a substantial reduction in neuronal size, abnormal neuronal migration and downregulation of gene expression, including that of the neurotrophin receptor TrkC, parvalbumin and Brn3b. Selective loss of TrkC neurons in the spiral ganglion of Brn3a(-/-) cochlea leads to an innervation defect similar to that of TrkC(-/-) mice. Most remarkably, our results uncover a novel role for Brn3a in regulating axon pathfinding and target field innervation by spiral and vestibular ganglion neurons. Loss of Brn3a results in severe retardation in development of the axon projections to the cochlea and the posterior vertical canal as early as E13,5. In addition, efferent axons that use the afferent fibers as a scaffold during pathfinding also show severe misrouting. Interestingly, despite the well-established roles of ephrins and EphB receptors in axon pathfinding, expression of these molecules does not appear to be affected in Brn3a(-/-) mice. Thus, Brn3a must control additional downstream genes that are required for axon pathfinding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:03:39