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Titolo:
Glycoinositolphospholipids, free and as anchors of proteins, in Trypanosoma cruzi
Autore:
de Lederkremer, RM; Bertello, LE;
Indirizzi:
Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, CIHIDECAR,RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1428 Aires, DF, Argentina
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 12, volume: 7, anno: 2001,
pagine: 1165 - 1179
SICI:
1381-6128(200108)7:12<1165:GFAAAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VARIANT SURFACE GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL MEMBRANE ANCHORS; GLYCOSYL PHOSPHATIDYLINOSITOL MYRISTOYLATION; ALPHA-GALACTOSYL ANTIBODIES; CROSS-REACTING DETERMINANT; O-LINKED OLIGOSACCHARIDES; THIN-LAYER CHROMATOGRAPHY; DECAY ACCELERATING FACTOR; CHRONIC CHAGAS-DISEASE; TRANS-SIALIDASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: de Lederkremer, RM Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, CIHIDECAR,Pabellon 2,Ciudad Univ, RA-1428 Buenos Aires, DF, Argentina Univ Buenos Aires Pabellon 2,Ciudad Univ Buenos Aires DF Argentina RA-1428
Citazione:
R.M. de Lederkremer e L.E. Bertello, "Glycoinositolphospholipids, free and as anchors of proteins, in Trypanosoma cruzi", CUR PHARM D, 7(12), 2001, pp. 1165-1179

Abstract

The most important glycoproteins of trypanosomatids are anchored by glycoinositolphospholipids (GIPLs) to their plasma membrane. In addition, free GIPLs have been described, for instance the lipopeptidophosphoglycan (LPPG) which is a major component of the surface of T. cruzi epimastigotes. An inositolphosphoceramide (IPC) is part of the LPPG and of glycoproteins present in different stages of T. cruzi. Ceramide was not found in mammal GIPL-anchors. The lipid moieties in T. cruzi anchors can be quite variable. However,mo diacylglycerol (DAG) was found in contrast with the African trypanosomes. In GIPLs of epimastigotes collected at the logarithmic phase of growth both, 1 -O-hexadecyl-2-O-palmitoylglycerol and ceramide were identified. Lignoceroylsphinganine is the major ceramide, however, no lignoceric acid was detected when analysing the candidate precursors IPCs, in any of the stagesof T. cruzi. An alkylglycerol has been found either as a lyse species in the Tc85 glycoprotein of trypomastigotes or acylated as in the 1G7 anchor ofmetacyclic forms and in the mucins of epimastigote forms. The lipid in themucins is replaced by ceramide when the parasite differentiates to metacyclic forms. Also, in the Ssp-4 glycoprotein characteristic of amastigotes, aceramide was identified as the anchor lipid. These variations suggest thata remodelling mechanism is working in T. cruzi. On the other hand, the oligosaccharide core in the GIPLs of T. cruzi is substituted with galactofuranose, This monosaccharide is found only in the pyranose configuration in mammalian glycoproteins and glycolipids. Thus, the biosynthetic steps for the introduction of galactofuranose and ceramide in the anchors of T. cruzi aregood targets for the development of therapeutic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:23:56