Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Recent developments in the chemotherapy of Chagas' disease
Autore:
Docampo, R;
Indirizzi:
Univ Illinois, Coll Vet Med, Dept Pathobiol, Mol Parasitol Lab, Urbana, IL61802 USA Univ Illinois Urbana IL USA 61802 Mol Parasitol Lab, Urbana, IL61802 USA
Titolo Testata:
CURRENT PHARMACEUTICAL DESIGN
fascicolo: 12, volume: 7, anno: 2001,
pagine: 1157 - 1164
SICI:
1381-6128(200108)7:12<1157:RDITCO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPANOSOMA SCHIZOTRYPANUM CRUZI; NITROGEN-CONTAINING BISPHOSPHONATES; ERGOSTEROL BIOSYNTHESIS INHIBITORS; FARNESYL PYROPHOSPHATE SYNTHASE; CYSTEINE PROTEASE INHIBITORS; IN-VITRO; FARNESYLTRANSFERASE INHIBITORS; DIPHOSPHATE SYNTHASE; STEROL BIOSYNTHESIS; FOLLOW-UP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Docampo, R Univ Illinois, Coll Vet Med, Dept Pathobiol, Mol Parasitol Lab,2001 S Lincoln Ave, Urbana, IL 61802 USA Univ Illinois 2001 S Lincoln Ave Urbana IL USA 61802 61802 USA
Citazione:
R. Docampo, "Recent developments in the chemotherapy of Chagas' disease", CUR PHARM D, 7(12), 2001, pp. 1157-1164

Abstract

Chagas' disease remains an important health problem in the Americas. Advances are being made in parts of South America in blocking transmission from insect vectors or blood transfusion, but more effective chemotherapy is needed for the millions who are already infected. This is especially importantsince recent results have indicated that treatment is beneficial for the elimination of the chronic course of the disease. The rational development of new drugs depends on the identification of differences between human metabolism and that of the causative parasite, Trypanosoma cruzi. Recent developments in the study of the basic biochemistry of the parasite have allowed the identification of novel targets for chemotherapy, such as sterol metabolism, protein prenylation, proteases, and phospholipid metabolism, and these are the subject of this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 10:53:28