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Titolo:
Ypt and Rab GTPases: insight into functions through novel interactions
Autore:
Segev, N;
Indirizzi:
Univ Illinois, Dept Biol Sci, Mol Biol Lab, Chicago, IL 60607 USA Univ Illinois Chicago IL USA 60607 i, Mol Biol Lab, Chicago, IL 60607 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 500 - 511
SICI:
0955-0674(200108)13:4<500:YARGII>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUANINE-NUCLEOTIDE EXCHANGE; ENDOCYTIC MEMBRANE-FUSION; ACTIVATING-PROTEIN GAP; CIS-SNARE COMPLEX; VESICULAR TRANSPORT; CRYSTAL-STRUCTURE; VESICLE DOCKING; EARLY ENDOSOMES; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; SECRETORY PATHWAY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Segev, N Univ Illinois, Dept Biol Sci, Mol Biol Lab, MBRB 4120,900 S Ashland Ave, Chicago, IL 60607 USA Univ Illinois MBRB 4120,900 S Ashland Ave Chicago IL USA 60607 SA
Citazione:
N. Segev, "Ypt and Rab GTPases: insight into functions through novel interactions", CURR OP CEL, 13(4), 2001, pp. 500-511

Abstract

Ypt/Rab GTPases are key regulators of vesicular transport in eukaryotic cells. During the past two years, a number of new Ypt/Rab-interacting proteins have been identified and shown to serve as either upstream regulators or downstream effecters. Proteins that interact with these regulators and effectors of Ypt/Rabs have also been identified, and together they provide new insights into Ypt/Rab mechanisms of action. The picture that emerges from these studies suggests that Ypt/Rabs function in multiple and diverse aspects of vesicular transport. In addition, not only are Ypt/Rabs highly conserved, but their functions and interactions are as well. Interestingly, crosstalk among Ypt/Rabs and between Ypt/Rabs and other signaling factors, suggest the possibility of coordination of the individual vesicular transport steps and of the protein transport machinery with other cellular processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:30:13