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Titolo:
Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients
Autore:
Muller, B; Peri, G; Doni, A; Torri, V; Landmann, R; Bottazzi, B; Mantovani, A;
Indirizzi:
Ist Ric Farmacol Mario Negri, Milan, Italy Ist Ric Farmacol Mario Negri Milan Italy acol Mario Negri, Milan, Italy Univ Brescia, Dept Pathol, Brescia, Italy Univ Brescia Brescia ItalyUniv Brescia, Dept Pathol, Brescia, Italy Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland Univ Basel Hosp Basel Switzerland CH-4031 ed, CH-4031 Basel, Switzerland
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 7, volume: 29, anno: 2001,
pagine: 1404 - 1407
SICI:
0090-3493(200107)29:7<1404:CLOTLP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; ACUTE-PHASE PROTEINS; AMYLOID-P COMPONENT; INTENSIVE-CARE UNIT; A-PROTEIN; FAMILY; MEMBER; MULTICENTER; EXPRESSION; CLONING;
Keywords:
pentraxins; C-reactive protein; infection; inflammation; sepsis; septic shock; critically ill patients; interleukin 6; calcitonin precursors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, B Ist Ric Farmacol Mario Negri, Milan, Italy Ist Ric Farmacol Mario Negri Milan Italy Negri, Milan, Italy
Citazione:
B. Muller et al., "Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients", CRIT CARE M, 29(7), 2001, pp. 1404-1407

Abstract

Objective: To evaluate the recently discovered long pentraxin PTX3 in plasma of critically ill patients and to compare it with the classic short pentraxin C-reactive protein and with other indicators of inflammation. Design: A cohort study on plasma samples. Setting: Medical intensive care unit (ICU) of the University Hospital of Basel. Patients: A total of 101 consecutive critically ill patients admitted to the medical ICU. Interventions: Venous blood samples were routinely obtained at entry, on day 2, and at discharge or before death. Measurements and Main Results: Plasma samples were obtained from 101 consecutive critically ill patients admitted to the ICU with systemic inflammatory response syndrome, sepsis, or septic shock. PTX3 plasma levels were measured by enzyme-linked immunosorbent assay. PTX3 was elevated in critically ill patients, with a gradient from systemic inflammatory response syndrome to septic shock. PTX3 levels correlated with clinical scores reflecting severity of disease (e.g., Acute Physiology and Chronic Health Evaluation II: p = .00097), In addition, high levels of PTX3 were associated with unfavorable outcome. Conclusions: The long pentraxin PTX3 is elevated in critically ill patients and correlates with severity of disease and infection. Compared with the short pentraxin C-reactive protein, PTX3 may be a more direct indicator of tissue involvement by inflammatory and infectious processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 00:56:00