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Titolo:
The contemporary management of acute myocardial infarction
Autore:
Almeda, FQ; Snell, RJ; Parrillo, JE;
Indirizzi:
Rush Presbyterian St Lukes Med Ctr, Div Cardiovasc Dis & Crit Care Med, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
CRITICAL CARE CLINICS
fascicolo: 2, volume: 17, anno: 2001,
pagine: 411 -
SICI:
0749-0704(200104)17:2<411:TCMOAM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; UNSTABLE ANGINA; THROMBOLYTIC THERAPY; CORONARY ANGIOPLASTY; CARDIOGENIC-SHOCK; TRIAL; IMMEDIATE; MORTALITY; HEPARIN; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Almeda, FQ Rush Presbyterian St Lukes Med Ctr, Div Cardiovasc Dis & Crit Care Med, 1653 W Congress Pkwy, Chicago, IL 60612 USA Rush Presbyterian St Lukes Med Ctr 1653 W Congress Pkwy Chicago IL USA 60612
Citazione:
F.Q. Almeda et al., "The contemporary management of acute myocardial infarction", CRIT CARE C, 17(2), 2001, pp. 411

Abstract

The acute coronary syndromes cover disease entities ranging from unstable angina and non-Q wave myocardial infarction (MI) to Q wave myocardial infarction. These syndromes share a common pathogenesis and represent various stages of plaque rupture and thrombosis with varying degrees of vessel occlusion and subsequent myocardial necrosisThe pathogenesis of acute coronary syndromes involves a vulnerable plaque that ruptures or fissures, initiating a cascade of inflammatory and thrombotic mediators in and around the coronary artery wall that results in varying degrees of arterial occlusion and distal microembolization.(23) Significant thrombotic coronary occlusion often develops in arteries that have only a minimal (10% to 40%) degree of stenosis at baseline.(21) The unstable and"vulnerable" plaque, not necessarily one that is severely stenotic, is most prone to rupture (Fig. 2). About 1.5 million cases of acute myocardial infarction occur every year inthe United States resulting in approximately 400,000 to 500,000 deaths peryear. The overall mortality rate ranges from 5% to 30% depending on specific patient characteristics, and about half die before reaching the hospital, usually because of ventricular arrhythmias. The in-hospital mortality is around 10% and most commonly is caused by cardiogenic shock.(36).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:46:07