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Titolo:
Pharmacologic treatment of the stunned myocardium: the concepts and the challenges
Autore:
Przyklenk, K;
Indirizzi:
Hosp Good Samaritan, Inst Heart, Los Angeles, CA 90017 USA Hosp Good Samaritan Los Angeles CA USA 90017 t, Los Angeles, CA 90017 USA Univ So Calif, Dept Med, Cardiol Sect, Los Angeles, CA USA Univ So Calif Los Angeles CA USA Med, Cardiol Sect, Los Angeles, CA USA
Titolo Testata:
CORONARY ARTERY DISEASE
fascicolo: 5, volume: 12, anno: 2001,
pagine: 363 - 369
SICI:
0954-6928(200108)12:5<363:PTOTSM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; CONSCIOUS RABBITS; CONTRACTILE DYSFUNCTION; EXCHANGE INHIBITION; NA+/H+ EXCHANGE; RECOVERY; REPERFUSION; MECHANISMS; CHANNELS; PHASE;
Keywords:
adenosine; antioxidants; ATP-sensitive potassium channels; calcium channel blockers; calcium sensitizing agents; nitric oxide; oxygen free radical scavengers; sodium-hydrogen exchange; inhibitors; troponin I;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Przyklenk, K Hosp Good Samaritan, Inst Heart, 1225 Wilshire Blvd, Los Angeles, CA 90017USA Hosp Good Samaritan 1225 Wilshire Blvd Los Angeles CA USA 90017
Citazione:
K. Przyklenk, "Pharmacologic treatment of the stunned myocardium: the concepts and the challenges", CORON ART D, 12(5), 2001, pp. 363-369

Abstract

During the past two decades (i.e., since 1980), in excess of 1000 published papers have focused on the phenomenon of the 'stunned myocardium', with many of these studies seeking to identify mechanisms-based treatment strategies to attenuate post-ischemic contractile dysfunction. Early investigations focused largely on abrogating the deleterious effects of oxygen-derived free radicals and unfavorable alterations in calcium homeostasis, both considered to contribute significantly to the pathogenesis of the stunned myocardium. More recently, favorable results have also been obtained using a somewhat different paradigm: that is, attempting to capitalize on endogenous cardioprotective mediators, most notably adenosine, nitric oxide, and the ATP-sensitive potassium channel. Now that potential therapeutic candidates have been identified in the experimental laboratory, the as-yet unmet challenge is to translate this information into the design of effective pharmacologic therapies to treat myocardial stunning in the clinical arena. Coron Artery Dis 12:363-369 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:07:08