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Titolo:
Gender difference in enzymes related with alcohol consumption in hamster, an avid consumer of alcohol
Autore:
Lee, SF; Chen, ZY; Fong, WP;
Indirizzi:
Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 3, volume: 129, anno: 2001,
pagine: 285 - 293
SICI:
1532-0456(200107)129:3<285:GDIERW>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYRIAN GOLDEN-HAMSTERS; RENIN-ANGIOTENSIN SYSTEM; CHOICE ETHANOL INTAKE; ALDEHYDE DEHYDROGENASE; METABOLISM; RAT; LIVER; INDUCTION; ISOZYMES; DAIDZIN;
Keywords:
alcohol dehydrogenase; alcohol intake; aldehyde dehydrogenase; angiotensin converting enzyme; catalase; cytochrome P450; gender difference; hamster; toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fong, WP Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
S.F. Lee et al., "Gender difference in enzymes related with alcohol consumption in hamster, an avid consumer of alcohol", COMP BIOC C, 129(3), 2001, pp. 285-293

Abstract

Syrian golden hamster (Mesocricetus auratus) is extraordinary among laboratory rodents in its ability to drink alcohol. After being given a free choice between 15% ethanol and water for 5 days, both male and female hamsters derived at least 85% of the fluid intake from the ethanol solution. Analysis of the alcohol-metabolizing enzymes in alcohol-naive hamsters showed thatthe male had a higher activity of 57%, 58% and 34% in stomach alcohol dehydrogenase, liver cytochrome P450 1A2 and liver aldehyde dehydrogenase, respectively, compared with the: female. The activity of lung angiotensin-converting enzyme, which influence fluid intake, was twofold higher in the male. After 4 weeks of ethanol consumption, the activities of the hepatic alcohol-metabolizing enzymes remained unchanged except cytochrome P450 2E1 which increased 42% and 88% in male and female hamsters, respectively. A reduction of similar to 80% In the activity of cytochrome P450 1A2 was observed in both genders. The activities of several other cytochrome P450 enzymes were also decreased, Although ethanol consumption did not increase plasma aminotransferase levels, it caused a significant increase in liver weight in female, but not male hamsters. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:53:27