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Titolo:
Granulocyte-colony stimulating factor and macrophage-colony stimulating factor in patients with non-small-cell lung cancer
Autore:
Mroczko, B; Szmitkowski, M; Niklinski, J;
Indirizzi:
Med Acad, Dept Biochem Diagnost, PL-15276 Bialystok, Poland Med Acad Bialystok Poland PL-15276 Diagnost, PL-15276 Bialystok, Poland Med Acad, Dept Thorac Surg, Bialystok, Poland Med Acad Bialystok PolandMed Acad, Dept Thorac Surg, Bialystok, Poland
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 5, volume: 39, anno: 2001,
pagine: 374 - 379
SICI:
1434-6621(200105)39:5<374:GSFAMS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONHEMATOPOIETIC TUMOR-CELLS; MALIGNANT MESOTHELIOMA; GM-CSF; LINES; RECEPTORS; CYTOKINE; EXPRESSION; INVITRO; GROWTH; GENES;
Keywords:
granulocyte-colony stimulating factor; macrophage-colony stimulating factor; lung cancer; non-small-cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Szmitkowski, M Med Acad, Dept Biochem Diagnost, M Sklodowska Curie 24A, PL-15276 Bialystok, Poland Med Acad M Sklodowska Curie 24A Bialystok Poland PL-15276
Citazione:
B. Mroczko et al., "Granulocyte-colony stimulating factor and macrophage-colony stimulating factor in patients with non-small-cell lung cancer", CLIN CH L M, 39(5), 2001, pp. 374-379

Abstract

We have investigated the serum level of granulocyte-colony stimulating factor (G-CSF) and macrophage-colony stimulating factor (M-CSF) in non-small-cell lung cancer (NSCLC), in relation to the control group and commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1). Additionally, we have defined the diagnostic sensitivity, specificity, positive predictive value, negative predictive value and receiver-operating characteristics (ROC) curve of G-CSF and M-CSF. Serum levels of cytokines were measured in 61 patients with NSCLC and in 20 healthy subjects. G-CSF and M-CSF were determined using ELISA. CYFRA 21-1 was measured by radioimmunoassay and CEA by microparticle enzyme immunoassay. There were significant increases in the level of circulating G-CSF in the lung cancer patients compared to the control group. Moreover, the diagnostic sensitivity of G-CSF was higher (56%) than the sensitivity of CYFRA 21-1 (51%), but lower than the CEA sensitivity (62%). The diagnostic specificity of G-CSF was higher (70%) than the M-CSF specificity (40%) and the G-CSF predictive values were higher in relation to the predictive values of M-CSF. These results suggest a potential role of G-CSF as a tumor marker for NSCLC.

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Documento generato il 24/01/20 alle ore 12:56:24