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Titolo:
High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomas
Autore:
Nishie, A; Masuda, K; Otsubo, M; Migita, T; Tsuneyoshi, M; Kohno, K; Shuin, T; Naito, S; Ono, M; Kuwano, M;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 em, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Pathol Anat, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 pt Pathol Anat, Fukuoka 8128582, Japan Kyushu Univ, Grad Sch Med Sci, Dept Urol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Sci, Dept Urol, Fukuoka 8128582, Japan Univ Occupat & Environm Hlth, Dept Mol Biol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Kochi Med Sch, Dept Urol, Kochi 7838505, Japan Kochi Med Sch Kochi Japan7838505 d Sch, Dept Urol, Kochi 7838505, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 7, volume: 7, anno: 2001,
pagine: 2145 - 2151
SICI:
1078-0432(200107)7:7<2145:HEOTCG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPPRESSION SUBTRACTIVE HYBRIDIZATION; ENDOTHELIAL GROWTH-FACTOR; HIPPEL-LINDAU DISEASE; DIFFERENTIAL EXPRESSION; THYMIDINE PHOSPHORYLASE; HEME OXYGENASE-1; BREAST-CANCER; ANGIOGENESIS; TUMORS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, M Kyushu Univ, Grad Sch Med Sci, Dept Med Biochem, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 ka 8128582, Japan
Citazione:
A. Nishie et al., "High expression of the Cap43 gene in infiltrating macrophages of human renal cell carcinomas", CLIN CANC R, 7(7), 2001, pp. 2145-2151

Abstract

We used suppression subtractive hybridization to identify highly expressedgenes in the cancerous region of human renal cell carcinoma (RCC) comparedwith noncancerous tissue. Nine genes were identified to show increased expression in the cancerous region compared with the noncancerous region. The nine genes included thymosin beta4 secreted protein acidic and rich in cysteine (SPARC), Cap43, cerulo-plasmin, serum amyloid A, osteopontin, heat shock protein 90 (HSP90), LOT1, and casein kinase I. Of these 9 genes, in situhybridization with LO clinical samples consistently showed a strong expression of Cap43 mRNA in infiltrating macrophages in RCCs, but not in cancer cells proliferating in an alveolar pattern, However, Cap43 mRNA was also apparently detected in epithelial cells of the renal proximal tubuli in noncancerous tissue. The higher expression of the Cap43 gene in the cancerous region of RCCs appears to depend on macrophage infiltration. Moreover, treatment with phorbol ester resulted in enhanced expression of the Cap43 gene in human monocytic cells in vitro. The expression of the Cap43 gene in infiltrating macrophages is discussed in association with the differentiated or activated status of monocyte/macrophage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:51:28