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Titolo:
Treatment of meningeal breast cancer xenografts in the rat using an anti-P185/HER2 antibody
Autore:
Bergman, I; Barmada, MA; Griffin, JA; Slamon, DJ;
Indirizzi:
Univ Pittsburgh, Med Ctr, Dept Pediat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Pediat, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Neurol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Neurol, Pittsburgh, PA 15213 USA Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 Pathol, Pittsburgh, PA 15213 USA Univ Calif Los Angeles, Sch Med, Div Hematol & Oncol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 7, volume: 7, anno: 2001,
pagine: 2050 - 2056
SICI:
1078-0432(200107)7:7<2050:TOMBCX>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; TUMOR-CELL LINES; MONOCLONAL-ANTIBODY; LEPTOMENINGEAL METASTASES; CARCINOMATOUS MENINGITIS; NEOPLASTIC XENOGRAFTS; HER-2/NEU ONCOPROTEIN; SIGNAL-TRANSDUCTION; PROGNOSTIC FACTORS; SOLID TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bergman, I Childrens Hosp Pittsburgh, 3705 5th Ave, Pittsburgh, PA 15213 USA Childrens Hosp Pittsburgh 3705 5th Ave Pittsburgh PA USA 15213
Citazione:
I. Bergman et al., "Treatment of meningeal breast cancer xenografts in the rat using an anti-P185/HER2 antibody", CLIN CANC R, 7(7), 2001, pp. 2050-2056

Abstract

The metastatic spread of breast cancer to the leptomeninges (LM) is a painful, debilitating, and usually lethal condition. Current therapies are generally ineffective or extremely toxic, The current study evaluated monoclonal antibody therapy in an animal model of LM human breast cancer, Monoclonalantibody 4D5, which recognizes the extracellular domain of the HER2/neu receptor, was administered into the cerebrospinal fluid of athymic rats implanted with human breast cancer cell lines. Continuous intraventricular administration of 4D5 inhibited growth of SKBR3 cells that overexpress HER2/neu but not of MCF7 cells, which do not. Inhibition was dose-dependent, with higher doses of 4D5 producing an improved response. i.p. administration of cisplatin in addition to 4D5 did not improve results, Continuous administration of 4D5 into the lumbar, as opposed to the ventricular intrathecal space,was not therapeutically effective. Treatment with 4D5 did not result in outgrowth of cells lacking expression of the HER2/neu receptor. These resultssuggest that 4D5, administered regionally, may palliate LM metastases fromHER2/neu-over-expressing breast carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:44:04