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Titolo:
Epidermal growth factor receptor and HER2-neu mRNA expression in non-smallcell lung cancer is correlated with survival
Autore:
Brabender, J; Danenberg, KD; Metzger, R; Schneider, PM; Park, JM; Salonga, D; Holscher, AH; Danenberg, PV;
Indirizzi:
Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Sch Med, Los Angeles, CA 90033 USA Univ So Calif, Dept Biochem & Mol Biol, Keck Sch Med, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Sch Med, Los Angeles, CA 90033 USA Univ Cologne, Dept Visceral & Vasc Surg, D-50931 Cologne, Germany Univ Cologne Cologne Germany D-50931 Vasc Surg, D-50931 Cologne, Germany
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 7, volume: 7, anno: 2001,
pagine: 1850 - 1855
SICI:
1078-0432(200107)7:7<1850:EGFRAH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HER-2/NEU GENE-EXPRESSION; CHI-SQUARE STATISTICS; INTRINSIC CHEMORESISTANCE; DIFFERENTIAL EXPRESSION; ESOPHAGEAL-CARCINOMA; SHORTENED SURVIVAL; P53; ADENOCARCINOMA; MUTATIONS; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Brabender, J Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, 1441 ELake Ave,NOR 5318, Los Angeles, CA 90033 USA Univ So Calif 1441 E Lake Ave,NOR 5318 Los Angeles CA USA 90033
Citazione:
J. Brabender et al., "Epidermal growth factor receptor and HER2-neu mRNA expression in non-smallcell lung cancer is correlated with survival", CLIN CANC R, 7(7), 2001, pp. 1850-1855

Abstract

The prognostic role of epidermal growth factor receptor (EGFR) and HER2-neu remains controversial in patients with non-small cell lung cancer (NSCLC), We studied the association between the mRNA expression of EGFR, HER2-neu,and survival in primary tumor and matching nonmalignant tissues from 83 patients with NSCLC, Analysis was performed using a quantitative real-time PCR system (Taqman), EGFR and HER2-neu mRNA expression was detectable in all (100%) specimens analyzed. Twenty-nine (34.9%) patients had high HER2-neu expression, and 28 (33.7%) patients had high EGFR expression, A high HER2-neu and EGFR coexpression was detectable in 14 (16.9 %) patients. High HER2-neu expression was associated with inferior survival (P = 0.004), whereas high EGFR expression showed a trend toward inferior survival (P = 0.176), Theimpact of HER2-neu and EGFR coexpression on patients ' survival was additive (P = 0.003), Multivariate analysis determined high HER2-neu expression (P = 0.041), and high EGFR/HER2-neu coexpression (P = 0.030) as significant and independent unfavorable prognostic factors. These findings indicate that HER2-neu and EGFR play a crucial role in the biological behavior of NSCLCs, Testing of molecular marker coexpression (EGFR and HER2-neu) improves the estimation of prognosis and appears to define low- and high-risk groups for treatment failure in curatively resected NSCLC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:03:50