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Titolo:
Effects of triamcinolone acetonide on microglial morphology and quantitative expression of MHC-II in exudative age-related macular degeneration
Autore:
Penfold, PL; Wong, JG; Gyory, J; Billson, FA;
Indirizzi:
Univ Sydney, Dept Clin Ophthalmol, Save Sight Inst, Sydney, NSW 2001, Australia Univ Sydney Sydney NSW Australia 2001 t Inst, Sydney, NSW 2001, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
fascicolo: 3, volume: 29, anno: 2001,
pagine: 188 - 192
SICI:
1442-6404(200106)29:3<188:EOTAOM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVITREAL TRIAMCINOLONE; NEOVASCULARIZATION; MODULATION;
Keywords:
macular degeneration; MHC-II; microglia; triamcinolone acetonide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Penfold, PL Univ Sydney, Dept Clin Ophthalmol, Save Sight Inst, GPO Box 4337, Sydney, NSW 2001, Australia Univ Sydney GPO Box 4337 Sydney NSW Australia 2001 , Australia
Citazione:
P.L. Penfold et al., "Effects of triamcinolone acetonide on microglial morphology and quantitative expression of MHC-II in exudative age-related macular degeneration", CLIN EXP OP, 29(3), 2001, pp. 188-192

Abstract

Animal models, in vitro assays and pilot clinical studies suggest that intravitreal triamcinolone acetonide may be useful in the treatment of age-related macular degeneration. The present case study reports the effect of intravitreal triamcinolone acetonide injection on a subretinal neovascular lesion, microglial morphology and quantitative expression of MHC-II antigens. Triamcinolone acetonide significantly decreased MHC-II expression consistent with immunocytochemical observations which revealed condensed microglial morphology. The modulation of subretinal oedema and microglial morphology correlates with in vitro observations suggesting that downregulation of inflammatory markers and endothelial cell permeability are significant featuresof the mode of action of triamcinolone acetonide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:14:11