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Titolo:
Lacryglobin in human tears, a potential marker for cancer
Autore:
Evans, V; Vockler, C; Friedlander, M; Walsh, B; Willcox, MDP;
Indirizzi:
Univ New S Wales, Cooperat Res Ctr Eye Res & Technol, Sch Optometry, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 y, Sydney, NSW 2052, Australia Univ Western Sydney Nepean, Sch Sci, Sydney, NSW, Australia Univ Western Sydney Nepean Sydney NSW Australia , Sydney, NSW, Australia Macquarie Univ, Australian Proteome Anal Facil, Sydney, NSW 2109, Australia Macquarie Univ Sydney NSW Australia 2109 cil, Sydney, NSW 2109, Australia Prince Wales Hosp, Oncol Day Ctr, Sydney, NSW, Australia Prince Wales Hosp Sydney NSW Australia l Day Ctr, Sydney, NSW, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
fascicolo: 3, volume: 29, anno: 2001,
pagine: 161 - 163
SICI:
1442-6404(200106)29:3<161:LIHTAP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTEROGLOBIN GENE FAMILY; BREAST-CANCER; MAMMAGLOBIN GENE; LYMPH-NODE; IDENTIFICATION; PROTEIN; MEMBER;
Keywords:
cancer; lacryglobin; mammaglobin; tears;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Evans, V Univ New S Wales, Cooperat Res Ctr Eye Res & Technol, Sch Optometry, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052, NSW 2052, Australia
Citazione:
V. Evans et al., "Lacryglobin in human tears, a potential marker for cancer", CLIN EXP OP, 29(3), 2001, pp. 161-163

Abstract

Lacryglobin has been identified in human tears. This protein has high sequence homology to the mammaglobins, proteins upregulated in breast cancer and in breast cancer metastasis. In order to investigate the utility of tear screening for cancer, tear samples were collected from patients with different types of cancer and compared to controls. Tear samples were taken from five controls and eight breast, six lung, five colon, one prostate and three ovary cancer patients. Tears were analysed using 2-D gel electrophoresis (n = 25) and 1-D electrophoresis (n = 3). Lacryglobin was present in the following percentage of patients: breast cancer (88%), lung (83%), colon (100%), ovary (33%), prostate (100%) and controls (60%). Two control patients with lacryglobin had a family history of breast and prostate cancer. Lacryglobin was detected in some but not all tear samples and further studies are warranted to investigate its potential as a marker for cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:04:37