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Titolo:
Influence of circadian time and age on glomerular angiotensin II receptorsin normotensive Sprague-Dawley and transgenic hypertensive TGR(mREN2)27 rats
Autore:
Lemmer, B; Rueff, T; Reiter, S; Huser, L; Hauptfleisch, S; Witte, K;
Indirizzi:
Univ Heidelberg, Fac Clin Med Mannheim, Inst Pharmacol & Toxicol, D-68169 Mannheim, Germany Univ Heidelberg Mannheim Germany D-68169 icol, D-68169 Mannheim, Germany
Titolo Testata:
CHRONOBIOLOGY INTERNATIONAL
fascicolo: 3, volume: 18, anno: 2001,
pagine: 447 - 459
SICI:
0742-0528(2001)18:3<447:IOCTAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; TGR(MREN-2)27 RATS; GENE-EXPRESSION; (MREN-2)27 RATS; DOWN-REGULATION; REN-2 GENE; AT(1); NATRIURESIS; PROFILES; SYSTEM;
Keywords:
angiotensin II receptor and mRNA; circadian; glomeruli; renal artery; Sprague-Dawley rat; transgenic hypertensive TGR(mREN2)27 rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lemmer, B Univ Heidelberg, Fac Clin Med Mannheim, Inst Pharmacol & Toxicol, Maybachstr 14-16, D-68169 Mannheim, Germany Univ Heidelberg Maybachstr 14-16 Mannheim Germany D-68169 rmany
Citazione:
B. Lemmer et al., "Influence of circadian time and age on glomerular angiotensin II receptorsin normotensive Sprague-Dawley and transgenic hypertensive TGR(mREN2)27 rats", CHRONOBIO I, 18(3), 2001, pp. 447-459

Abstract

In male heterozygous transgenic hypertensive rats, TGR(mREN2)27 (TGR), exhibiting an inverse blood pressure profile and in normotensive Sprague-Dawley (SPRD) controls, the density and affinity of angiotensin II receptors were determined at six circadian times in glomeruli of animals 11 weeks old kept under light-dark 12h:12 (LD 12:12) conditions. Angiotensin II receptors were also studied in rats 18-20 weeks old of both strains at 2h after lightonset. As a measure of renal excretory functions, diuresis, creatinine, and protein excretion were monitored using metabolic cages. The expression ofangiotensin II receptor mRNA was determined in renal arteries 2h-4h after light onset. The following results were obtained: (1) Renal excretory functions showed significant daily variation, with higher excretion rates in thedark span in both TGR and SPRD rats. (2) No circadian phase dependency wasfound in the glomerular angiotensin II receptors in both rat strains. However, receptor density was significantly lower in TGR than in SPRD rats. In both strains, receptor number increased with aging. (3) In renal arteries, the angiotensin II receptor mRNA of the main receptor subtype AT,, was neither strain nor age dependent, AT(1B)- and AT(2)-receptor mRNAs were significantly lower in TGR than SPRD rats. In conclusion, the results demonstrate that the overactive renin-angiotensin system in TGR rats led to a downregulation of glomerular angiotensin II receptor:, that was not accompanied by adown-regulation of the mRNA of the dominant AT(1A)- receptor subtype. Circadian short-term variations in blood pressure in both TGR and SPRD rats arenot reflected by daily variation in angiotensin II receptor density of renal glomeruli or by variation in receptor expression in renal vascular tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:04:31