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Titolo:
AP-1 mediated retinal photoreceptor apoptosis is independent of N-terminalphosphorylation of c-Jun
Autore:
Grimm, C; Wenzel, A; Behrens, A; Hafezi, F; Wagner, EF; Reme, CE;
Indirizzi:
Univ Zurich Hosp, Dept Ophthalmol, CH-8091 Zurich, Switzerland Univ ZurichHosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Inst Neuropathol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Inst Mol Pathol, A-1030 Vienna, Austria Inst Mol Pathol Vienna Austria A-1030 Mol Pathol, A-1030 Vienna, Austria
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 8, volume: 8, anno: 2001,
pagine: 859 - 867
SICI:
1350-9047(200108)8:8<859:AMRPAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-INDUCED APOPTOSIS; CELL-DEATH; MACULAR DEGENERATION; MUTANT RHODOPSIN; MESSENGER-RNA; DNA-REPAIR; RAT RETINA; HA-RAS; FOS; MICE;
Keywords:
apoptosis; AP-1; c-Jun; photoreceptor; phosphorylation; JunAA; light-induced degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Grimm, C Univ Zurich Hosp, Dept Ophthalmol, Frauenklinikstr 24, CH-8091 Zurich, Switzerland Univ Zurich Hosp Frauenklinikstr 24 Zurich Switzerland CH-8091 d
Citazione:
C. Grimm et al., "AP-1 mediated retinal photoreceptor apoptosis is independent of N-terminalphosphorylation of c-Jun", CELL DEAT D, 8(8), 2001, pp. 859-867

Abstract

Apoptosis is essential for retinal development but it is also a major modeof cell loss in many human retinal dystrophies. High levels of visible light induce retinal apoptosis in mice and rats. This process is dependent on the induction of the transcription factor AP-1, a dimeric complex composed of c-Fos and c-Jun/JunD phosphoproteins. While c-Fos is essential, JunD is dispensable for light-induced photoreceptor apoptosis. Here we show that N-terminal phosphorylation of c-Jun, the other main partner of c-Fos in induced AP-1 complexes is not required for programmed cell death during retinal development in vivo and is also dispensable for photoreceptor apoptosis induced by the exogenous stimuli 'excessive light' and N-nitroso-N-methylurea (MNU), Mice expressing a mutant c-Jun protein (JunAA) that cannot be phosphorylated at its N-terminus are apoptosis competent and their retina is not distinguishable from wild-type mice, Accordingly, Jun kinase, responsible for phosphorylation of wild-type c-Jun protein is at best only marginally induced by the apoptotic stimuli 'light' and MNU, Complex composition of light-induced AP-1 complexes is similar in wild-type and JunAA mice. This showsthat the mutant c-Jun protein can be part of the DNA binding complex AP-1 and demonstrates that induction of the DNA binding activity of AP-I after light insult does not depend on N-terminal phosphorylation of c-Jun, Our results suggest that transactivation of target genes by phosphorylated c-jun/AP-1 is not required for MNU- or light-induced apoptosis of photoreceptor cells.

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Documento generato il 19/01/20 alle ore 20:31:20