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Titolo:
Lipoxygenases and their involvement in programmed cell death
Autore:
Maccarrone, M; Melino, G; Finazzi-Agro, A;
Indirizzi:
Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 iochem Sci, I-00133 Rome, Italy
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 8, volume: 8, anno: 2001,
pagine: 776 - 784
SICI:
1350-9047(200108)8:8<776:LATIIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID METABOLISM; ERYTHROLEUKEMIA K562 CELLS; INDUCED APOPTOSIS; CANCER-CELLS; COLORECTAL-CANCER; ACTIVATION; 5-LIPOXYGENASE; INDUCTION; PATHWAY; RESVERATROL;
Keywords:
arachidonate; calcium; membranes; mitochondrial uncoupling; peroxidation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Finazzi-Agro, A Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
M. Maccarrone et al., "Lipoxygenases and their involvement in programmed cell death", CELL DEAT D, 8(8), 2001, pp. 776-784

Abstract

Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and the synthesis of signaling molecules. Consequently, they induce structural and metabolic changes in the cell in a number of pathophysiological conditions. Recently, a pro-apoptotic effect of lipoxygenase, and of the hydroperoxides produced thereof, has been reported in different cells and tissues, leading to cell death. Anti-apoptotic effects of lipoxygenases have also been reported; however, this has often been based on the use of enzyme inhibitors, Here we review the characteristics of the lipoxygenase family and its involvement in theinitiation of oxidative stress-induced apoptosis. Finally, we discuss the role of lipoxygenase activation in apoptosis of animal and plant cells, suggesting a common signal transduction pathway in cell death conserved through evolution of both kingdoms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:52:50