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Titolo:
The pulmonary vasculature in a neonatal porcine model with increased pulmonary blood flow and pressure
Autore:
Stenbog, EV; Steinbruchel, DA; Thomsen, AB; Baandrup, U; Heickendorff, L; Ingerslev, J; Andersen, NT; Emmettsen, K;
Indirizzi:
Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Cardiol, DK-8000 Aarhus, Denmark Univ Aarhus, Dept Cardiothorac Surg, Aarhus, Denmark Univ Aarhus Aarhus Denmark hus, Dept Cardiothorac Surg, Aarhus, Denmark Univ Aarhus, Inst Pathol, Aarhus, Denmark Univ Aarhus Aarhus DenmarkUniv Aarhus, Inst Pathol, Aarhus, Denmark Univ Aarhus, Dept Clin Biochem, Aarhus, Denmark Univ Aarhus Aarhus Denmark v Aarhus, Dept Clin Biochem, Aarhus, Denmark Univ Aarhus, Ctr Haemophilia & Thrombosis, Aarhus, Denmark Univ Aarhus Aarhus Denmark tr Haemophilia & Thrombosis, Aarhus, Denmark Univ Aarhus, Dept Biostat, Aarhus, Denmark Univ Aarhus Aarhus DenmarkUniv Aarhus, Dept Biostat, Aarhus, Denmark
Titolo Testata:
CARDIOLOGY IN THE YOUNG
fascicolo: 4, volume: 11, anno: 2001,
pagine: 420 - 430
SICI:
1047-9511(200107)11:4<420:TPVIAN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL HEART-DISEASE; PLASMA ENDOTHELIN-1; HYPERTENSION; DYSFUNCTION; SHUNTS;
Keywords:
hypertensive pulmonary vascular disease; pulmonary hypertension; congenital heart disease; endothelin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Stenbog, EV Aarhus Univ Hosp, Dept Cardiothorac Surg, Sect SKS, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N DK-8200 Aarhus N, Denmark
Citazione:
E.V. Stenbog et al., "The pulmonary vasculature in a neonatal porcine model with increased pulmonary blood flow and pressure", CARD YOUNG, 11(4), 2001, pp. 420-430

Abstract

Introduction: Hypertension and hyperperfusion of the pulmonary vascular bed in the setting of congenital cardiac malformations may lead to progressive pulmonary vascular disease. To improve the understanding of the basic mechanisms of this disease, there is a need for clinically relevant animal models which reflect the disease process, Material and Results: We randomly allocated 45 newborn pips, at the age of 48 hrs, to groups in which there waseither construction of a 3 mm central aorto-pulmonary shunt, undertaken in9, or ligation of the left pulmonary artery, achieved in 13. Controls included sham operations in 13, or no operations in 10 pigs. Follow-up was continued for three months. The interventions were compatible with survival in most pigs. The shunts resulted in an acute 85% increase in systolic pulmonary arterial pressure, and a more than twofold increase in pulmonary blood flow. By three months of age, nearly all shunts had closed spontaneously, and haemodynamics were normal. Ligation of the left pulmonary artery resultedin a normal total pulmonary blood flow, despite only the right lung being perfused, and a 33% increase in systolic pulmonary arterial pressure. Thesehaemodynamic changes were maintained throughout the period of study. In both groups, histomorphometry revealed markedly increased muscularity of the intra-acinar pulmonary arteries. Circulating levels of endothelin were normal in the shunted animals, and elevated in those with ligation of the left pulmonary artery. Conclusion: In neonatal porcine models of pulmonary vascular disease, created by construction of 3 mm central aorto-pulmonary shuntsand ligation of one pulmonary artery, we observed histopathological changes of the pulmonary vasculature similar to early hypertensive pulmonary vascular disease in humans. Elevated circulating levels of endothelin were associated with abnormal haemodynamics rather than abnormal pathology These findings could be valuable for future studies on the pathogenesis of hypertensive pulmonary vascular disease associated with congenital cardiac malformations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:44:04