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Titolo:
Cancer procoagulant and blood platelet activation
Autore:
Olas, B; Wachowicz, B; Mielicki, WP;
Indirizzi:
Univ Lodz, Inst Biochem, Dept Gen Biochem, PL-90237 Lodz, Poland Univ Lodz Lodz Poland PL-90237 , Dept Gen Biochem, PL-90237 Lodz, Poland Med Univ Lodz, Dept Biochem, IBSIB, PL-90151 Lodz, Poland Med Univ Lodz Lodz Poland PL-90151 Biochem, IBSIB, PL-90151 Lodz, Poland
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 169, anno: 2001,
pagine: 165 - 171
SICI:
0304-3835(20010828)169:2<165:CPABPA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-X; TUMOR-MARKER; COAGULATION; THROMBIN; BREAST; ASSAY;
Keywords:
blood platelets; aggregation; secretion; cancer procoagulant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wachowicz, B Univ Lodz, Inst Biochem, Dept Gen Biochem, Banacha 12-16, PL-90237 Lodz, Poland Univ Lodz Banacha 12-16 Lodz Poland PL-90237 37 Lodz, Poland
Citazione:
B. Olas et al., "Cancer procoagulant and blood platelet activation", CANCER LETT, 169(2), 2001, pp. 165-171

Abstract

The effects of cancer procoagulant (CP), cysteine protease (EC 3.4.22.26),on the pig blood platelet secretory process and platelet aggregation have been studied. The response of platelets to CP was compared with the response of these cells to thrombin. The obtained results show that blood platelets treated with CP (0.5, 1, 2.5, and 5 mug/ml, 2-30 min, 37 degreesC) released adenine nucleotides (P < 0.05) and proteins (P < 0.05). The secretion ofcompounds from blood platelets after incubation with CP does not correlatewith the release of platelet lactic dehydrogenase activity (marker of celllysis) into the extracellular medium. In comparison with thrombin action, CP stimulates secretory process to a smaller extent than thrombin alone. Inthe presence of CP, the thrombin action is suppressed (P < 0.05). We noticed that CP does not induce platelet aggregation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:00:06