Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Human leukocyte antigens (HLA)-Cw as prognostic indicators in autologous transplantation for lymphoma
Autore:
Skerrett, D; Rosina, O; Bodian, C; Isola, L; Gudzowaty, O; Scigliano, E; Fruchtman, S;
Indirizzi:
Mt Sinai Med Ctr, Dept Med, Blood Bank, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 Blood Bank, New York, NY 10029 USA Mt Sinai Med Ctr, Dept Med, Bone Marrow Transplantat Serv, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 antat Serv, New York, NY 10029 USA Mt Sinai Med Ctr, Dept Biomath, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 pt Biomath, New York, NY 10029 USA
Titolo Testata:
CANCER INVESTIGATION
fascicolo: 5, volume: 19, anno: 2001,
pagine: 487 - 494
SICI:
0735-7907(2001)19:5<487:HLA(AP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; VERSUS-HOST DISEASE; HLA-C DISPARITY; MHC CLASS-I; MARROW TRANSPLANTATION; INHIBITORY RECEPTORS; CORD-BLOOD; NK CELLS; UNRELATED DONORS; RECOGNITION;
Keywords:
autologous transplantation outcome; HLA-Cw; prognostic indicators;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Skerrett, D Columbia Univ Coll Phys & Surg, Dept Pathol Transfus Med, 622 W 168th St,HP4-419, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 622 W 168th St,HP4-419 New York NY USA 10032
Citazione:
D. Skerrett et al., "Human leukocyte antigens (HLA)-Cw as prognostic indicators in autologous transplantation for lymphoma", CANCER INV, 19(5), 2001, pp. 487-494

Abstract

The human leukocyte antigens (HLA) function as a transplantation antigens and as markers in disease association. Disparity at the HLA A, B, Cw and DRloci in allogenic stem cell transplants results in an increased incidence of graft-versus-host disease, graft rejection, and decreased survival. HLA class I loci A, B, and Cw also function as ligands for natural killer (NK) cell receptors in an interaction that predominantly inhibits cytolysis of target antigens. This HLA-NK cell inhibitory function is required for protection against auto-aggression, and is of unclear significance in other clinical settings. Furthermore, the prevention of auto-aggression is HLA molecule specific as demonstrated by the association of specific HLA types with autoimmune diseases. It is not known whether HLA molecules might serve as markers for outcome in autologous transplants. We investigated as association of HLA class I molecules and early transplant outcome in a cohort of patients who underwent autologous transplantation for the treatment of lymphoma. In this retrospective study, HLA class I molecules were analysed to determine whether they affect the transplant outcome. HLA typing was performed by microlymphocytotoxicity assays. Factors such as age, sex, disease type, lactate dehydrogenase (LDH), cell dose, type of graft, and transfusion events were reviewed. Outcome was defined as death (or survival) at 6 months from the date of transplant. HLA-Cw8 was significantly associated with poor outcome (odds ratio = 18 and 9.3, p = 0.01 and 0.02 in homozygous and all patients, respectively). The HLA-A and B locus molecules were not associated with outcome. Age, sex, elevated LDH, and cell dose were not associated with outcome. A blood progenitor cell dose of greater than 6 x 10(8) nucleated cells/kg was favorably associated with outcome. In the multivariate analysis of HLAs and factors associated with outcome (p = 0.03) following autologoustransplantation in lymphoma patients. The association of HLA-Cw molecules with outcome in this study group indicates a need for further investigationof HLA-mediated interactions that affect antitumor cytotoxicity, cytokine release, and regimen related toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:22:09