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Titolo:
New insight into MyoD regulation: involvement in rhabdomyosarcoma pathway?
Autore:
Tintignac, LA; Leibovitch, MP; Leibovitch, SA;
Indirizzi:
Inst Gustave Roussy, Lab Genet Oncol, UMR 1599 CNRS, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France
Titolo Testata:
BULLETIN DU CANCER
fascicolo: 6, volume: 88, anno: 2001,
pagine: 545 - 548
SICI:
0007-4551(200106)88:6<545:NIIMRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
FRE
Soggetto:
CELL-CYCLE; KINASE-ACTIVITY; TERMINAL DIFFERENTIATION; MUSCLE-CELLS; MYOGENESIS; PHOSPHORYLATION; DEGRADATION; EXPRESSION; INDUCTION; MYOBLASTS;
Keywords:
MyoD; degradation; cell cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tintignac, LA Inst Gustave Roussy, Lab Genet Oncol, UMR 1599 CNRS, Rue Camille Desmoulins, F-94805 Villejuif, France Inst Gustave Roussy Rue Camille Desmoulins Villejuif France F-94805
Citazione:
L.A. Tintignac et al., "New insight into MyoD regulation: involvement in rhabdomyosarcoma pathway?", B CANCER, 88(6), 2001, pp. 545-548

Abstract

The transcription factor MyoD, member of the myogenic regulators family, induced differentiation in precursor cells by its ability to arrest cell proliferation and to activate muscle specific genes. MyoD plays a key role in the antagonism between proliferation and to activate muscle specific genes. MyoD plays a key role in the antagonism between proliferation and differentiation. The withdrawal from the cell cycle and the activation of muscle differentiation are related to the level of MyoD protein. The cyclin E-cdk2 complex, one of the key regulators of the G1/S transition is directly implicated in the degradation of MyoD by the ubiquitin-proteasome pathway, leading the myoblasts to proliferate. The display of this control in normal myoblasts suggest that its deficiency in the muscle stem cells could lead to theformation of rhabdomyosarcomas which have lost both the control of cell proliferation and the transcriptional activity of MyoD.

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Documento generato il 29/09/20 alle ore 10:23:56