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Titolo:
Post-menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women
Autore:
Cushman, M; Psaty, BM; Meilahn, EN; Dobs, AS; Kuller, LH;
Indirizzi:
Univ Vermont, Dept Med, Burlington, VT USA Univ Vermont Burlington VT USA niv Vermont, Dept Med, Burlington, VT USA Univ Vermont, Dept Pathol, Burlington, VT USA Univ Vermont Burlington VT USA Vermont, Dept Pathol, Burlington, VT USA Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Hlth Serv, Seattle, WA 98195 USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Johns Hopkins Univ, Dept Med, Baltimore, MD USA Johns Hopkins Univ Baltimore MD USA ns Univ, Dept Med, Baltimore, MD USA
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 114, anno: 2001,
pagine: 162 - 168
SICI:
0007-1048(200107)114:1<162:PHTACO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC VENOUS THROMBOEMBOLISM; CARDIOVASCULAR RISK-FACTORS; REPLACEMENT THERAPY; POSTMENOPAUSAL WOMEN; PULMONARY-EMBOLISM; USERS; COAGULATION; VARIABLES; FIBRINOLYSIS; ASSOCIATION;
Keywords:
oestrogen replacement therapy; blood coagulation; venous thrombosis; protein C; antithrombin III;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Cushman, M Univ Vermont, 208 S Pk Dr,Suite 2, Colchester, VT 05446 USA Univ Vermont 208 S Pk Dr,Suite 2 Colchester VT USA 05446 46 USA
Citazione:
M. Cushman et al., "Post-menopausal hormone therapy and concentrations of protein C and antithrombin in elderly women", BR J HAEM, 114(1), 2001, pp. 162-168

Abstract

The effects of post-menopausal hormone therapy (HRT) on blood coagulation in elderly women are not well defined. We studied associations of HRT use with levels of natural anticoagulant proteins in a cross-sectional study of 3393 women greater than or equal to 65 years of age participating in the Cardiovascular Health Study. Protein C antigen and antithrombin were measuredin all users (n = 230 unopposed oestrogen; 60 oestrogen/progestin) and a comparison group of 196 age- and race-matched non-users. Compared with non-users, oestrogen use was associated with higher protein C (4.80 vs. 4.30 mug/ml, P < 0.01). Results were similar for oestrogen/progestin (P > 0.05). Inboth user groups, antithrombin was lower than in non-users (109% for each vs. 115% in non-users, P < 0.001). Adjustment for factors related to prescription of HRT and to anticoagulant protein levels had little impact on the results. For antithrombin, associations with HRT were larger for thinner Caucasian women and black women. Venous thrombosis from HRT may be mediated partly by alterations in antithrombin, but not protein C concentrations. This study extends previous observations to older women, the group at highest risk of venous thromboembolism. Studies of HRT-induced alterations in anticoagulant function in relation to the occurrence of thrombosis with HRT are required.

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Documento generato il 01/12/20 alle ore 08:11:24