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Titolo:
In vivo expansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces B-cell leukaemia in mice
Autore:
Holyoake, TL; Freshney, MG; Samuel, K; Ansell, J; Watson, GE; Wright, EG; Graham, GJ; Pragnell, IB;
Indirizzi:
Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland Beatson Inst CancRes Glasgow Lanark Scotland G61 1BD D, Lanark, Scotland Univ Edinburgh, Western Gen Hosp, Leukaemia Res Fund, John Hughes Bennett Lab, Edinburgh, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland burgh, Midlothian, Scotland Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Cellular Pathol, Dundee DD1 9SY, Scotland Univ Dundee Dundee Scotland DD1 9SY lar Pathol, Dundee DD1 9SY, Scotland
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 114, anno: 2001,
pagine: 49 - 56
SICI:
0007-1048(200107)114:1<49:IVEOTE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCULUS Y-CHROMOSOME; LEUKEMIA; IMMUNOGLOBULIN; PROLIFERATION; AUTOIMMUNE; CAPACITY; ABILITY; INVIVO;
Keywords:
B cell; leukaemia; bone marrow transplantation (BMT); CD5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Holyoake, TL Univ Glasgow, Royal Infirm, Dept Med, 10 Alexandra Parade, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow 10 Alexandra Parade Glasgow Lanark Scotland G31 2ER
Citazione:
T.L. Holyoake et al., "In vivo expansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces B-cell leukaemia in mice", BR J HAEM, 114(1), 2001, pp. 49-56

Abstract

Chronic lymphocytic leukaemia (CLL) is a malignancy of CD5(+) B cells. This B-cell lineage is established during ontogeny and replenished by the process of self-renewal. Spontaneous and induced leukaemias that frequently affect this lineage are thought to arise as a result of the frequent cell division required to maintain the population throughout adulthood and in response to repeated exposure to environmental antigens. In a series of bone marrow transplant (BMT) experiments performed in B6D2F1 mice, B-cell leukaemia occurred in recipients of serially transplanted syngeneic bone marrow. Thisstudy was therefore designed to determine the frequency and phenotype of the observed leukaemia. Male donor cells were initially transplanted into lethally irradiated female hosts and secondary (2 degrees) BMT was performed at 3 months. At 1, 2, 3 and 16 months following primary (1 degrees) BMT, and when 2 degrees BMT recipients developed leukaemia, animals were sacrificed and their tissues extensively examined. These analyses confirmed a host-derived CD5(+) transplantable B-cell leukaemia that was initiated in 50% of 1 degrees BMT recipients. With serial passage, the leukaemia became more aggressive and lost CD5 expression, suggesting transformation to a high-gradeleukaemia/lymphoma. This previously unreported observation suggests that the combination of radiation and subsequent serial transplantation induces aproliferative stress to the host B-cell compartment that is causative in leukaemic transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:46:52