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Titolo:
FK506 ameliorates the discrimination learning impairment due to preventingthe rarefaction of white matter induced by chronic cerebral hypoperfusion in rats
Autore:
Tanaka, K; Hori, K; Wada-Tanaka, N; Nomura, M; Ogawa, N;
Indirizzi:
Okayama Univ, Grad Sch Med & Dent, Dept Brain Sci, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 ept Brain Sci, Okayama 7008558, Japan Rikkyo Univ, Dept Psychol, Toshima Ku, Tokyo 1718501, Japan Rikkyo Univ Tokyo Japan 1718501 sychol, Toshima Ku, Tokyo 1718501, Japan Saitama Med Sch, Dept Physiol, Moroyama, Saitama 3500495, Japan Saitama Med Sch Moroyama Saitama Japan 3500495 ma, Saitama 3500495, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 906, anno: 2001,
pagine: 184 - 189
SICI:
0006-8993(20010706)906:1-2<184:FATDLI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; CYCLOSPORINE-A; IMMUNOPHILIN LIGANDS; REPERFUSION INJURY; MEMORY FORMATION; BRAIN ISCHEMIA; WISTAR RATS; IN-VIVO; IMMUNOSUPPRESSANT; CALCINEURIN;
Keywords:
white matter ischemia; immunophilin ligand; discrimination learning; demyelination; neuronal cell death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, K Okayama Univ, Grad Sch Med & Dent, Dept Brain Sci, 2-5-1 ShikataCho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 558, Japan
Citazione:
K. Tanaka et al., "FK506 ameliorates the discrimination learning impairment due to preventingthe rarefaction of white matter induced by chronic cerebral hypoperfusion in rats", BRAIN RES, 906(1-2), 2001, pp. 184-189

Abstract

We examined the effects of the immunosuppressant tacrolimus (FK506) on thediscrimination learning impairment induced by chronic cerebral hypoperfusion in rats. Chronic cerebral hypoperfusion was prepared by permanent ligation of bilateral common carotid arteries for male Wistar rats aged 9 weeks. FK506 (0.05 mg/kg, s.c.) recovered the learning impairment and also prevented the rarefaction of white matter and striatal neuronal cell damage. Our findings suggest that FK506 ameliorates the learning impairment mainly due to preventing neuropathological alterations. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 24/01/20 alle ore 13:12:35