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Titolo:
Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP+) into the striatum is associated with hydroxyl free radical generation
Autore:
Obata, T; Yamanaka, Y; Kinemuchi, H; Oreland, L;
Indirizzi:
Oita Med Univ, Dept Pharmacol, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 iv, Dept Pharmacol, Oita 8795593, Japan Ishinomaki Senshu Univ, Fac Sci & Engn, Biochem Lab, Ishinomaki 9868580, Japan Ishinomaki Senshu Univ Ishinomaki Japan 9868580 shinomaki 9868580, Japan Uppsala Univ, Ctr Biomed, Dept Neurosci, Pharmacol Sect, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 rmacol Sect, S-75124 Uppsala, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 906, anno: 2001,
pagine: 170 - 175
SICI:
0006-8993(20010706)906:1-2<170:RODBPW>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL NITRIC-OXIDE; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; LIPID-PEROXIDATION; INTRACRANIAL MICRODIALYSIS; NEURODEGENERATIVE DISEASES; SYNTHASE INHIBITOR; MPTP NEUROTOXICITY; BRAIN DIALYSIS; RAT STRIATUM;
Keywords:
1-methyl-4-phenylpyridinium ion (MPP+); dopamine; hydroxyl radical; reserpine; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Obata, T Oita Med Univ, Dept Pharmacol, 1-1 Hasama Machi, Oita 8795593, Japan Oita Med Univ 1-1 Hasama Machi Oita Japan 8795593 8795593, Japan
Citazione:
T. Obata et al., "Release of dopamine by perfusion with 1-methyl-4-phenylpyridinium ion (MPP+) into the striatum is associated with hydroxyl free radical generation", BRAIN RES, 906(1-2), 2001, pp. 170-175

Abstract

In Parkinson's disease (PD), the dopamine (DA) neuronal cell death in the nigrostriatal system has been proposed to be mediated by reactive oxygen radicals such as hydroxyl radicals (OH). This OH production may cause lipid peroxidation of cell membranes leading to neuronal cell death. This paper report that the DA-selective neurotoxin, 1-methyl-4-phenylpyridinium ion (MPP), (1 nmol/mul per min for 1 h) infusion into the striatum of rats induceselevation of extracellular DA and OH formation. These elevations seem to induce lipid peroxidation of striatum membranes. as detected by increases innon-enzymatic formation of 2,3-dihydroxybenzoic acid (DHBA) levels. To test the involvement of DA release in the OH generation and lipid peroxidation, the rats were pretreated with reserpine (5 mg/kg, i.v., 24 h before MPP+ or without MPP+) to deplete presynaptic DA. Reserpine treatment alone did not change the levels of DA or 2,3-DHBA. while the combined treatment with both MPP+ and reserpine clearly decreased 2,3-DHBA, as well as DA levels, compared to those in the group treated with MPP+ alone. After injection into reserpinized rats. DA at various doses (2, 5 and 10 muM) small increased 2,3-DHBA levels dose-dependently, as compared to the MPP+ alone-treated group. These results clearly indicate that MPP+ perfusion into the striatum increases extracellular DA levels and this increase may concomitantly induce the formation of reactive free oxygen radicals, such as OH free radicals. These events may contribute, at least in part, to the nigrostriatal neurons cell death after MPP+ (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:20:22