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Titolo:
Motoric behavior in aged rats treated with GM1
Autore:
Goettl, VM; Wemlinger, TA; Colvin, AE; Neff, NH; Hadjiconstantinou, M;
Indirizzi:
Ohio State Univ, Coll Med & Publ Hlth, Dept Psychiat, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 pt Psychiat, Columbus, OH 43210 USA Ohio State Univ, Coll Med & Publ Hlth, Dept Pharmacol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 t Pharmacol, Columbus, OH 43210 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 906, anno: 2001,
pagine: 92 - 100
SICI:
0006-8993(20010706)906:1-2<92:MBIART>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; STRIATAL DOPAMINE RELEASE; LOCOMOTOR-ACTIVITY; NEUROTRANSMITTER SYSTEMS; CONTAINING NEURONS; FISCHER-344 RAT; IN-VIVO; GANGLIOSIDE; DEFICITS; BRAIN;
Keywords:
aging; motoric behavior; D1 and D2 dopamine receptors; nigrostriatal neurons; GM1 ganglioside;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Hadjiconstantinou, M Ohio State Univ, Coll Med & Publ Hlth, Dept Psychiat,Graves Hall,Room 5034,333 W 10th Ave, Columbus, OH 43210 USA Ohio State Univ Graves Hall,Room 5034,333 W 10th Ave Columbus OH USA 43210
Citazione:
V.M. Goettl et al., "Motoric behavior in aged rats treated with GM1", BRAIN RES, 906(1-2), 2001, pp. 92-100

Abstract

Aging is associated with impaired motor function. Nigrostriatal dopaminergic neurons, in part, regulate motoric behavior, and undergo degenerative changes during aging. GM1 ganglioside partially restores pre-synaptic dopaminergic markers and the number and morphology of dopaminergic neurons in the midbrain and striatum of Sprague-Dawley aged rats. These studies investigated whether GM1 treatment. 30 mg/kg, i.p. daily for 36 days, affects locomotor and stereotypic activity, as well as coordination, balance, and strengthin aged rats. Under the treatment conditions used, GM1 did not improve thereduced locomotor and stereotypic behavior of the aged rats. While it partially improved performance on a square bridge test. GM1 had no effect on inclined screen and rod suspension tests. Although GM1 restored the decreasedcontent of dopamine and homovanillic acid in the nigrostriatal neurons of the aged rats, it had no effect on the reduced D1 and D2 dopamine receptor binding and mRNA in the striatum. It appears, that despite the morphological and metabolic restoration of aged nigrostriatal neurons, GM1 has limited ability in improving age-associated motor deficits. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 09:52:02