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Titolo:
Decline in motor functions in aging is related to the loss of NMDA receptors
Autore:
Ossowska, K; Wolfarth, S; Schulze, G; Wardas, J; Pietraszek, M; Lorenc-Koci, E; Smialowska, M; Coper, H;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 eurobiol, PL-31343 Krakow, Poland Free Univ Berlin, Dept Clin Neurobiol, D-14050 Berlin, Germany Free Univ Berlin Berlin Germany D-14050 urobiol, D-14050 Berlin, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 907, anno: 2001,
pagine: 71 - 83
SICI:
0006-8993(20010713)907:1-2<71:DIMFIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; EXCITATORY AMINO-ACIDS; PARKINSONS-DISEASE; MUSCLE TONE; ELECTROMYOGRAPHIC ACTIVITY; GLUTAMATE RECEPTORS; STRETCH REFLEX; SPATIAL MEMORY; AUTORADIOGRAPHIC ANALYSIS; SYNAPTIC PLASTICITY;
Keywords:
aging; motor dysfunction; NMDA receptor; AMPA receptor; dopamine D2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Ossowska, K Polish Acad Sci, Inst Pharmacol, Dept Neuropsychopharmacol, 12Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 w, Poland
Citazione:
K. Ossowska et al., "Decline in motor functions in aging is related to the loss of NMDA receptors", BRAIN RES, 907(1-2), 2001, pp. 71-83

Abstract

The aim of the study was to assess the contribution of central dopaminergic and glutamatergic systems to the age-dependent loss of motor functions inrats. Rats of three age groups were compared: young (3-5-month-old), middle-aged (20-21-month-old) and old (29-31-month-old). The obtained results showed an age-dependent decline in the electromyographic (EMG) resting and reflex activities in the gastrocnemius and tibialis anterior muscles, as wellas in the T-maze performance. Although these disturbances were accompaniedwith significant age-dependent decreases in the binding to NMDA, AMPA and dopamine D2 receptors, and a decline in the number of nigral dopamine neurons, they were significantly correlated with the loss of the binding to NMDAreceptors only. The reduction in T-maze performance with aging was additionally correlated with a decrease in motor functions (EMG activity). The study suggests a crucial role of the loss of NMDA receptors in age-dependent motor disabilities, as well as in disturbances measured in the T-maze. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:53:28