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Titolo:
Characteristics of 15314 hypertensive patients at high coronary risk. The VALUE Trial
Autore:
Kjeldsen, SE; Julius, S; Brunner, H; Hansson, L; Henis, M; Ekman, S; Laragh, J; McInnes, G; Smith, B; Weber, M; Zanchetti, A;
Indirizzi:
Ullevaal Univ Hosp, Dept Cardiol, NO-0407 Oslo, Norway Ullevaal Univ HospOslo Norway NO-0407 ept Cardiol, NO-0407 Oslo, Norway Univ Michigan, Div Hypertens, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 v Hypertens, Ann Arbor, MI 48109 USA Univ Lausanne, Lausanne, Switzerland Univ Lausanne Lausanne SwitzerlandUniv Lausanne, Lausanne, Switzerland Univ Uppsala, Dept Geriatr, Uppsala, Sweden Univ Uppsala Uppsala SwedenUniv Uppsala, Dept Geriatr, Uppsala, Sweden Novartis Pharma, E Hanover, NJ USA Novartis Pharma E Hanover NJ USANovartis Pharma, E Hanover, NJ USA Novartis Pharma, Basel, Switzerland Novartis Pharma Basel SwitzerlandNovartis Pharma, Basel, Switzerland New York Hosp, Cornell Med Ctr, New York, NY 10021 USA New York Hosp New York NY USA 10021 rnell Med Ctr, New York, NY 10021 USA Univ Glasgow, Western Infirm, Gardiner Inst, Dept Med & Therapeut, GlasgowG11 6NT, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G11 6NT gowG11 6NT, Lanark, Scotland State Univ New York, Brooklyn, NY USA State Univ New York Brooklyn NY USA tate Univ New York, Brooklyn, NY USA Univ Milan, Osped Maggiore, Ctr Fisiol Clin & Ipertens, Milan, Italy Univ Milan Milan Italy ggiore, Ctr Fisiol Clin & Ipertens, Milan, Italy Inst Auxol Italiano, Milan, Italy Inst Auxol Italiano Milan ItalyInst Auxol Italiano, Milan, Italy
Titolo Testata:
BLOOD PRESSURE
fascicolo: 2, volume: 10, anno: 2001,
pagine: 83 - 91
SICI:
0803-7051(2001)10:2<83:CO1HPA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; ISOLATED SYSTOLIC HYPERTENSION; RANDOMIZED TRIAL; BLOOD-PRESSURE; CARDIOVASCULAR MORBIDITY; ACTIVE TREATMENT; SWEDISH TRIAL; OLD PATIENTS; MORTALITY; NIFEDIPINE;
Keywords:
amlodipine; angiotensin II antagonist; angiotensin receptor blocker; calcium antagonist; cardiovascular risk; hypertension; mortality-morbidity; valsartan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kjeldsen, SE Ullevaal Univ Hosp, Dept Cardiol, NO-0407 Oslo, Norway Ullevaal Univ Hosp Oslo Norway NO-0407 NO-0407 Oslo, Norway
Citazione:
S.E. Kjeldsen et al., "Characteristics of 15314 hypertensive patients at high coronary risk. The VALUE Trial", BLOOD PRESS, 10(2), 2001, pp. 83-91

Abstract

Valsartan is an orally active, selective antagonist of the angiotensin II-1 (AT1) receptor developed for the treatment of hypertension. The ValsartanAntihypertensive Long-term Use Evaluation (VALUE) Trial of Cardiovascular Events in Hypertension in a double-blind, randomized prospective, parallel group study designed to compare the effects of valsartan with those of the calcium-antagonist amlodipine on the reduction of cardiac morbidity and mortality. Patients with essential hypertension, aged 50 years and older, and at particularly high risk of coronary events were enrolled. 18 119 patientswere screened and 15314 patients in 31 countries were randomized mainly between January 1998 and December 1999. These hypertensives had a mean blood pressure of 154.7/87.5 mmHg at the time of their randomization to blinded medication. The population comprises both genders (men 57.6%), Caucasians (89.1%), mean age 67.2 years, mean body mass index 28.6 kg/m(2), coronary heart disease (45.8%), high cholesterol (33.0%), type 2 diabetes mellitus (31.7%) and smokers (24.0%). More than 92% of the randomized participants had been treated for high blood pressure for at least 6 months when screened forthe study. The randomized population is now being treated (goal blood pressure < 140/90 mmHg) in adherence with the protocol until at least 1450 patients experience primary cardiac endpoint defined as clinically evident or aborted myocardial infarction, hospitalization for heart failure or death caused by coronary heart disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:19:08