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Titolo:
Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma
Autore:
Baltaci, S; Orhan, D; Gogus, C; Turkolmez, K; Tulunay, O; Gogus, O;
Indirizzi:
Ankara Univ, Sch Med, Dept Urol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 d, Dept Urol, TR-06100 Ankara, Turkey Ankara Univ, Sch Med, Dept Pathol, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 Dept Pathol, TR-06100 Ankara, Turkey
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 88, anno: 2001,
pagine: 100 - 103
SICI:
1464-4096(200107)88:1<100:INOSEI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL CARCINOMA; CANCER; BLADDER;
Keywords:
nitric oxide synthase; benign prostatic hyperplasia; prostatic intraepithelial neoplasia; prostate cancer; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Baltaci, S Fahrettin Altay Cad, Guzin Sok 50-6, TR-06130 Ankara, Turkey Fahrettin Altay Cad Guzin Sok 50-6 Ankara Turkey TR-06130 rkey
Citazione:
S. Baltaci et al., "Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low- and high-grade prostatic intraepithelial neoplasia and prostatic carcinoma", BJU INT, 88(1), 2001, pp. 100-103

Abstract

Objective To elucidate the incidence of inducible nitric oxide synthase (iNOS) expression in benign prostatic hyperplasia (BPH), low- and high-grade prostatic intraepithelial neoplasia (PIN) and prostatic carcinoma lesions, and to explore the role of iNOS in prostate tumorigenesis. Materials and methods Immunoreactivity for iNOS was examined in 20 sampleseach of BPH, high-grade PIN, low-grade PIN and prostatic carcinoma. Results Positive iNOS immunostaining was detected in all samples from all patients; iNOS was detected in both basal epithelial cells and secretory cells of the glandular epithelium. High-grade PIN and prostatic carcinoma samples had more intense iNOS immunostaining than low-grade PIN and BPH samples, In all samples, smooth muscle cells showed weal; or moderate iNOS immunoreactivity and endothelial cells showed moderate immunostaining. Conclusions Nitric oxide generated by iNOS may be involved in prostate tumorigenesis and further studies with immunohistochemical and molecular biology are needed to determine the exact role of iNOS in the pathogenesis oif prostatic carcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:47:46