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Titolo:
The effect of methylene blue on histological damage after spermatic cord torsion in a rat model
Autore:
Greenstein, A; Schreiber, L; Matzkin, H;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Urol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 t Urol, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Pathol, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Pathol, IL-64239 Tel Aviv, Israel
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 88, anno: 2001,
pagine: 90 - 92
SICI:
1464-4096(200107)88:1<90:TEOMBO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPERFUSION INJURY; ISCHEMIA-REPERFUSION; TESTICULAR TORSION;
Keywords:
testicular torsion; methylene blue; oxygen-free radicals; histological damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Greenstein, A Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Urol, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 Israel
Citazione:
A. Greenstein et al., "The effect of methylene blue on histological damage after spermatic cord torsion in a rat model", BJU INT, 88(1), 2001, pp. 90-92

Abstract

Objective To investigate, in a rat model, whether methylene blue (a free-radical scavenger) is effective in alleviating the histological testicular damage caused by reperfusion after spermatic cord torsion. Materials and methods Male Wistar rats underwent a clockwise 720 degrees left spermatic cord torsion lasting 3 h; they were then randomly assigned totreatment and control groups. Ln the treated group, 2 mg/kg methylene bluewas injected intraperitoneally 20 min before the cord was untwisted, and an additional 1 mg/kg injected into the penile vein 1-2 min beforehand. After 14 days, the left testicle was removed and assessed histologically. The control group was not treated. Results Thirty-three rats in the treatment group and 35 untreated controlswere suitable for evaluation. Treatment with methylene blue was not significantly predictive of histological damage; the colour of the testis before detorsion was not correlated with histological damage. Conclusion Anti-oxidant treatment with methylene blue had no palliative effect on the histological changes after torsion and detorsion of the spermatic cord in this rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:18:14