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Titolo:
Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease:a preliminary report
Autore:
Biagiotti, G; Cavallini, G;
Indirizzi:
Andros Italia, Ferrara Outpatient Clin, I-44100 Ferrara, Italy Andros Italia Ferrara Italy I-44100 patient Clin, I-44100 Ferrara, Italy Andros Italia, Perugia, Italy Andros Italia Perugia ItalyAndros Italia, Perugia, Italy
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 1, volume: 88, anno: 2001,
pagine: 63 - 67
SICI:
1464-4096(200107)88:1<63:AVTITO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPIONYL-L-CARNITINE; HEART-MITOCHONDRIA; PLACEBO;
Keywords:
Peyronie's disease; acetyl-L-carnitine; tamoxifen; oral therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Cavallini, G Andros Italia, Ferrara Outpatient Clin, Via Mascheraio 46, I-44100 Ferrara, Italy Andros Italia Via Mascheraio 46 Ferrara Italy I-44100 Italy
Citazione:
G. Biagiotti e G. Cavallini, "Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease:a preliminary report", BJU INT, 88(1), 2001, pp. 63-67

Abstract

Objective To detect whether oral acetyl-L-carnitine might be useful in theacute and early chronic phases of Peyronie's disease, compared with tamoxifen, a drug currently in use. Patients and methods The study included 48 patients with Peyronie's disease (15 acute and 33 initial chronic), randomized equally into two groups, The fist group used tamoxifen 20mg twice daily for 3 months and the second acetyl-L-carnitine Ig twice daily for 3 months, The disease and stages were diagnosed and identified using a history, objective examination, pharmacologically induced erection, autophotography during erection, and basic and dynamic colour Doppler ultrasonography, Penile curvature, plaque size, pain and disease progression were assessed. The differences between the groups or between the variables before and after therapy were compared using analysisof variance or the chi-squared test. Results Acetyl-L-carnitine was significantly more effective than tamoxifenin reducing pain and in inhibiting disease progression. Acetyl-L-carnitinereduced penile curvature significantly, while tamoxifen did not; both drugs significantly reduced plaque size. Tamoxifen induced significantly more side-effects than acetyl-L-carnitine. Conclusions These results suggest that acetyl-L-carnitine is significantlymore effective and safe than tamoxifen in the therapy of acute and early chronic Peyronie's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:21:48