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Titolo:
An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers
Autore:
Ellis, KA; Stough, C; Vitetta, L; Heinrich, K; Nathan, PJ;
Indirizzi:
Swinburne Univ Technol, Brain Sci Inst, Neuropharmacol Lab, Hawthorn, Vic 3122, Australia Swinburne Univ Technol Hawthorn Vic Australia 3122 n, Vic 3122, Australia Swinburne Univ Technol, Sch Biophys Sci & Elect Engn, Neuropsychol Lab, Hawthorn, Vic 3122, Australia Swinburne Univ Technol Hawthorn Vic Australia 3122 n, Vic 3122, Australia Swinburne Univ Technol, Grad Sch Integrated Med, Hawthorn, Vic 3122, Australia Swinburne Univ Technol Hawthorn Vic Australia 3122 n, Vic 3122, Australia Cognit Drug Res Ltd, Reading, Berks, England Cognit Drug Res Ltd Reading Berks England s Ltd, Reading, Berks, England
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 3, volume: 12, anno: 2001,
pagine: 173 - 182
SICI:
0955-8810(200106)12:3<173:AIITAN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING-MEMORY PERFORMANCE; OBJECT RECOGNITION TASK; INTRASEPTAL INFUSIONS; EXTRACT LI-160; SCOPOLAMINE; RATS; DOPAMINE; DIAZEPAM; ANTAGONIST; MODULATION;
Keywords:
hypericum; St. John's Wort; pharmacology; memory; nootropic; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Nathan, PJ Swinburne Univ Technol, Brain Sci Inst, Neuropharmacol Lab, 400Burwood Rd, Hawthorn, Vic 3122, Australia Swinburne Univ Technol 400 Burwood Rd Hawthorn Vic Australia 3122
Citazione:
K.A. Ellis et al., "An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers", BEHAV PHARM, 12(3), 2001, pp. 173-182

Abstract

Hypericum perforatum L, (St, John's Wort) is a complex herb that has been used for centuries for its putative medicinal properties, and has current therapeutic relevance as a treatment of mild to moderate depression. Recently, two studies in rodents have suggested that hypericum may also have memory-enhancing effects. It has a complex pharmacology, in that acute administration modulates numerous neurotransmitter systems that have previously beenobserved to either augment or impair a variety of memory processes in humans. This study aimed to examine whether acute administration of standardized hypericum extract could exert a nootropic effect in normal human subjects. The study employed a double-blind, crossover, repeated-measures design. Twelve healthy young subjects completed the Cognitive Drug Research (CDR) memory battery, following administration of placebo, 900 mg and 1800 mg hypericum (Blackmore's Hyperiforte), The findings suggested that hypericum does not have an acute nootropic effect in healthy humans at these doses. However, there was some evidence for an impairing effect on accuracy of numeric working memory and delayed picture recognition at the higher dose. This observed impairment could be due to a sensitivity of these specific tasks to modulation by neurotransmitters that have been noted to have memory-impairingeffects (e.g. gamma -aminobutyric acid (GABA), serotonin), (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 05/04/20 alle ore 23:03:51